A2BIU4 · MTAP_HYPBU

Function

function

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site20phosphate (UniProtKB | ChEBI)
Binding site62-63phosphate (UniProtKB | ChEBI)
Binding site95-96phosphate (UniProtKB | ChEBI)
Site175Important for substrate specificity
Binding site194substrate
Binding site195phosphate (UniProtKB | ChEBI)
Binding site218-220substrate
Site229Important for substrate specificity

GO annotations

AspectTerm
Molecular FunctionS-methyl-5-thioadenosine phosphorylase activity
Biological ProcessL-methionine salvage from methylthioadenosine
Biological Processpurine ribonucleoside salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    S-methyl-5'-thioadenosine phosphorylase
  • EC number
  • Alternative names
    • 5'-methylthioadenosine phosphorylase
      (MTA phosphorylase
      ; MTAP
      )

Gene names

    • Name
      mtnP
    • Ordered locus names
      Hbut_0022

Organism names

Accessions

  • Primary accession
    A2BIU4

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004151041-274S-methyl-5'-thioadenosine phosphorylase

Interaction

Subunit

Homohexamer. Dimer of a homotrimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    274
  • Mass (Da)
    30,784
  • Last updated
    2007-02-20 v1
  • Checksum
    305ED09C45DDCE01
MPDFPPKPSVKADIAIIGGSGLYDPGVLENAKEYKIYTPYGEPSDYIIVGELGGKRVAFLPRHGRGHRIPPHKINYRANIWALKMLGVKWVIAVSAVGSLREDYKPGDIVVPDQFIDMTKSRVYTFFDEGIVAHVSMADPFCEHLRQEIISTARELGYRVHPRGTYICIEGPRFSTRAESRVWREVFKADIIGMTLVPEVNLACEAQLCYATIALVTDYDVWAERPVTAEEVARVMKENTEKAKKILYKLIPRLPPEPDKARCSCCSSLETALL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000493
EMBL· GenBank· DDBJ
ABM79900.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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