A2BID8 · A2BID8_DANRE
- ProteinAmyloid beta (A4) precursor-like protein 2
- Geneaplp2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids764 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endomembrane system | |
Cellular Component | membrane | |
Molecular Function | heparin binding | |
Molecular Function | serine-type endopeptidase inhibitor activity | |
Molecular Function | transition metal ion binding | |
Biological Process | axonogenesis | |
Biological Process | central nervous system development |
Keywords
- Ligand
Protein family/group databases
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA2BID8
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 695-717 | Helical | ||||
Sequence: ALIGLLVIAVAIATVIVISLVLL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-20 | |||||
Sequence: MGSVPAVSVLILAIAVPSLA | ||||||
Chain | PRO_5035034875 | 21-764 | ||||
Sequence: GYIEALAANAGTGFAVAEPQVAMFCGKLNMHINIQTGRWEPDPSGSKTCVGTKEGVLQYCQEIYPELQITNVVEANQPVKIENWCKKDKKQCKGHAHIVVPYKCLVGEFVSDVLLVPEKCKFFHKERMDMCVSHQQWHGVAKEACSKGNMVLHSYGMLLPCGIDKFHGTEYVCCPSTRPEEPAPPASPSKEMDDEDDDDEEEEDVEEPVVEEDEEDDEDAVDESEPVAIDPPTQEDTAEEEEEQEEDGDEEDYHYIYEDEEEDRDSEEKDVKKEKAVMPEKQDDDKTLQEVEAVCSLEAETGPCRASMPRWHFDMQQRKCVRFIYGGCAGNRNNFDSEEYCMVVCKRLTVPPTPQPTDDVDVYFETPADDKEHSRFQKAKEQLEIRHRNRMERVRKEWEEAESQARNLPKAERQTLIQHFQAMVESLEEEAASEKQQLVETHLARVEAMLNDRRRLALENYLAALQADPPRPHRILQALKRYVRAENKDRQHTIRHYQHVLAVDPEKAAQMKSQVMTHLRVIEERMNQSLSLLYKVPYVAEEIQDEIDELLQVQKADMDQFLSSISESQPDVTVSSEESVEVPAFEGKPFRPFQVNSLGSPAEPEGSGMNSLDGLIGAEEKVINSKNKINENVVIDETLDVKEVILNGVDPLFSRGSEQESFRPLVDDFSFGSSALIGLLVIAVAIATVIVISLVLLRKRQYGTISHGIVEVDPMLTPEERHLSKMQNHGYENPTYKYLEQMQI | ||||||
Disulfide bond | 45↔69 | |||||
Sequence: CGKLNMHINIQTGRWEPDPSGSKTC | ||||||
Disulfide bond | 80↔124 | |||||
Sequence: CQEIYPELQITNVVEANQPVKIENWCKKDKKQCKGHAHIVVPYKC | ||||||
Disulfide bond | 105↔112 | |||||
Sequence: CKKDKKQC | ||||||
Disulfide bond | 140↔194 | |||||
Sequence: CKFFHKERMDMCVSHQQWHGVAKEACSKGNMVLHSYGMLLPCGIDKFHGTEYVCC | ||||||
Disulfide bond | 151↔181 | |||||
Sequence: CVSHQQWHGVAKEACSKGNMVLHSYGMLLPC | ||||||
Disulfide bond | 165↔193 | |||||
Sequence: CSKGNMVLHSYGMLLPCGIDKFHGTEYVC |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 35-130 | GFLD subdomain | ||||
Sequence: AVAEPQVAMFCGKLNMHINIQTGRWEPDPSGSKTCVGTKEGVLQYCQEIYPELQITNVVEANQPVKIENWCKKDKKQCKGHAHIVVPYKCLVGEFV | ||||||
Domain | 35-196 | E1 | ||||
Sequence: AVAEPQVAMFCGKLNMHINIQTGRWEPDPSGSKTCVGTKEGVLQYCQEIYPELQITNVVEANQPVKIENWCKKDKKQCKGHAHIVVPYKCLVGEFVSDVLLVPEKCKFFHKERMDMCVSHQQWHGVAKEACSKGNMVLHSYGMLLPCGIDKFHGTEYVCCPS | ||||||
Region | 138-196 | CuBD subdomain | ||||
Sequence: EKCKFFHKERMDMCVSHQQWHGVAKEACSKGNMVLHSYGMLLPCGIDKFHGTEYVCCPS | ||||||
Region | 196-307 | Disordered | ||||
Sequence: STRPEEPAPPASPSKEMDDEDDDDEEEEDVEEPVVEEDEEDDEDAVDESEPVAIDPPTQEDTAEEEEEQEEDGDEEDYHYIYEDEEEDRDSEEKDVKKEKAVMPEKQDDDKT | ||||||
Compositional bias | 211-245 | Acidic residues | ||||
Sequence: EMDDEDDDDEEEEDVEEPVVEEDEEDDEDAVDESE | ||||||
Compositional bias | 254-285 | Acidic residues | ||||
Sequence: QEDTAEEEEEQEEDGDEEDYHYIYEDEEEDRD | ||||||
Compositional bias | 286-307 | Basic and acidic residues | ||||
Sequence: SEEKDVKKEKAVMPEKQDDDKT | ||||||
Domain | 315-365 | BPTI/Kunitz inhibitor | ||||
Sequence: CSLEAETGPCRASMPRWHFDMQQRKCVRFIYGGCAGNRNNFDSEEYCMVVC | ||||||
Domain | 379-570 | E2 | ||||
Sequence: DVDVYFETPADDKEHSRFQKAKEQLEIRHRNRMERVRKEWEEAESQARNLPKAERQTLIQHFQAMVESLEEEAASEKQQLVETHLARVEAMLNDRRRLALENYLAALQADPPRPHRILQALKRYVRAENKDRQHTIRHYQHVLAVDPEKAAQMKSQVMTHLRVIEERMNQSLSLLYKVPYVAEEIQDEIDEL | ||||||
Coiled coil | 437-464 | |||||
Sequence: IQHFQAMVESLEEEAASEKQQLVETHLA |
Sequence similarities
Belongs to the APP family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length764
- Mass (Da)86,612
- Last updated2007-07-10 v2
- Checksum45E445DCDFD207BB
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2R8Q4V0 | A0A2R8Q4V0_DANRE | aplp2 | 776 | ||
A0A8M9P166 | A0A8M9P166_DANRE | aplp2 | 757 | ||
A0A8M9PA77 | A0A8M9PA77_DANRE | aplp2 | 745 | ||
A0A8M9PFK9 | A0A8M9PFK9_DANRE | aplp2 | 720 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 211-245 | Acidic residues | ||||
Sequence: EMDDEDDDDEEEEDVEEPVVEEDEEDDEDAVDESE | ||||||
Compositional bias | 254-285 | Acidic residues | ||||
Sequence: QEDTAEEEEEQEEDGDEEDYHYIYEDEEEDRD | ||||||
Compositional bias | 286-307 | Basic and acidic residues | ||||
Sequence: SEEKDVKKEKAVMPEKQDDDKT |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX908399 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CT573112 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC160603 EMBL· GenBank· DDBJ | AAI60603.1 EMBL· GenBank· DDBJ | mRNA |