A2BGR3 · ERC6L_DANRE
- ProteinDNA excision repair protein ERCC-6-like
- Geneercc6l
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1451 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro).
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | kinetochore | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | ATP-dependent chromatin remodeler activity | |
Molecular Function | DNA binding | |
Molecular Function | DNA translocase activity | |
Molecular Function | helicase activity | |
Biological Process | cell division | |
Biological Process | intein-mediated protein splicing |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA excision repair protein ERCC-6-like
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA2BGR3
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Localizes to kinetochores, inner centromeres and thin threads connecting separating chromosomes even during anaphase.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000328833 | 1-1451 | DNA excision repair protein ERCC-6-like | |||
Sequence: MESNNVEEVTDKFGGCLSLDTEKMGKYDRYRQKGKEAALNGELPRALELFQLAYQLQPSEKLKKRIQAIQDLIQREDEEDEEEEEEFVNVNNSGLKLYKGLYDKLYDHQKEGVAFLYSLYRDGRKGGILADDMGLGKTIQVISFLSGMYDAELANHTLLVMPTSLIKNWVREFAKWTPGMRVKEFHGSSKTERNRNLERIQRKGGVIITTYQMLINNYEQLGSNGHREFKWDYVILDEAHKIKTSSTKTAKSAHAIPAKNRVLLTGTPVQNNLREMWALFDFACQGSLLGTSKTFKTEYENPITRAREKDATPGEKALGLRISQNLTDIIKPYFLRRTKADVQQKKLKLEEGFEEEEDQENKCPNAREGVEMPSLTRKNDLIVWTYLSSVQEDIYNKFISLDQIKELLTTTRSPLAELTVLKKLCDHPRLLSQRAVIQLGLERGSDSELVHSDESESAVSQIDNISDHTLIEESGKLQFVVSLMECLREEGHRTLIFSQSRKMLDIMERVLRNRNFRLLRLDGTVTQLAEREKRISLFQTDKRYTIFLLTTQVGGVGITLTGANRVVIFDPSWNPATDAQAVDRAYRIGQTENVIIYRLITCGTVEEKIYRRQVFKDSLIRQTTGDKKNPFRYFSKQELRELFKLEDTRSSSTQQQLQAMHAQSRRSDTSLDHHIARLHSMEMFGISDHDLMFTKEPAADEDDPEDAESHHYIQTRVQKAQELMQAESELHGQLLDSMAQNTEPAWLRQMGQPNSSIRDRPAPPRIKNEPVTVDLTHNSFDEPEFEEDEQNLPSAEDAEMETASEDVEVIGDEDLGDKVISSEVEVVGEEVEVVAEEVEDAGEVEVVSEEVEGVGVEVEDVGVEVEDAGVEVEDAGVEVEDAGVEVEDAGEVEVVSGEGQVQPKSPQSGGEWNLQIVKTEVSPIAEKFADVITLDDTSDEADSSDFNTESKQQNSSQRFQSPSLQFPKLDDLSGASNTLGNEEVEPEKCHSQVLSSPLSQHEATTDEPFKAEMEMPHGNFNLLLEDSADMYFPEDEEVHEVEESAAEESPEFQLQMDVSGERLEEPSINHDKQNNGEFVNYNDSEVSKRESLLKIRSTPNESVDDSFVHSVRTKKRQVISDTEEEEEEEEESEKPCLTSSPFIDAISRLGSSTPKAVLVDGARLRRSLNASVASRRSFVVSLLENESDEESNEDKTKSSGASETCADELVEEVQTSSGDNSKSYETSEANGTLADELVEEEGEYREGKNTSDKVSESNETHSEEFAEEEKPSGDKSESYEISEASETHTDNSEEEIIGDHTGSYKISESSEADESVVEEEEPSGETLNTEESEMGEEEESAELIAGQEQEEWHSAVLESTGDVELDSNETMDQCAPKTVPVETHVLPVSSTNTAAEASDNKYNLLVLSGKQSLAEGRKQEALDFFLKAIDINTGDPEIQLLIIQLYRQLSQ | ||||||
Modified residue | 961 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for repeat, domain, motif, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 27-60 | TPR 1 | ||||
Sequence: YDRYRQKGKEAALNGELPRALELFQLAYQLQPSE | ||||||
Domain | 118-286 | Helicase ATP-binding | ||||
Sequence: SLYRDGRKGGILADDMGLGKTIQVISFLSGMYDAELANHTLLVMPTSLIKNWVREFAKWTPGMRVKEFHGSSKTERNRNLERIQRKGGVIITTYQMLINNYEQLGSNGHREFKWDYVILDEAHKIKTSSTKTAKSAHAIPAKNRVLLTGTPVQNNLREMWALFDFACQG | ||||||
Motif | 237-240 | DEAH box | ||||
Sequence: DEAH | ||||||
Domain | 479-639 | Helicase C-terminal | ||||
Sequence: FVVSLMECLREEGHRTLIFSQSRKMLDIMERVLRNRNFRLLRLDGTVTQLAEREKRISLFQTDKRYTIFLLTTQVGGVGITLTGANRVVIFDPSWNPATDAQAVDRAYRIGQTENVIIYRLITCGTVEEKIYRRQVFKDSLIRQTTGDKKNPFRYFSKQEL | ||||||
Region | 647-669 | Disordered | ||||
Sequence: DTRSSSTQQQLQAMHAQSRRSDT | ||||||
Compositional bias | 648-665 | Polar residues | ||||
Sequence: TRSSSTQQQLQAMHAQSR | ||||||
Region | 778-804 | Disordered | ||||
Sequence: NSFDEPEFEEDEQNLPSAEDAEMETAS | ||||||
Compositional bias | 781-804 | Acidic residues | ||||
Sequence: DEPEFEEDEQNLPSAEDAEMETAS | ||||||
Region | 935-1006 | Disordered | ||||
Sequence: DDTSDEADSSDFNTESKQQNSSQRFQSPSLQFPKLDDLSGASNTLGNEEVEPEKCHSQVLSSPLSQHEATTD | ||||||
Compositional bias | 947-980 | Polar residues | ||||
Sequence: NTESKQQNSSQRFQSPSLQFPKLDDLSGASNTLG | ||||||
Region | 1035-1054 | Disordered | ||||
Sequence: DEEVHEVEESAAEESPEFQL | ||||||
Region | 1063-1083 | Disordered | ||||
Sequence: LEEPSINHDKQNNGEFVNYND | ||||||
Region | 1096-1140 | Disordered | ||||
Sequence: RSTPNESVDDSFVHSVRTKKRQVISDTEEEEEEEEESEKPCLTSS | ||||||
Compositional bias | 1107-1121 | Basic and acidic residues | ||||
Sequence: FVHSVRTKKRQVISD | ||||||
Region | 1182-1343 | Disordered | ||||
Sequence: LLENESDEESNEDKTKSSGASETCADELVEEVQTSSGDNSKSYETSEANGTLADELVEEEGEYREGKNTSDKVSESNETHSEEFAEEEKPSGDKSESYEISEASETHTDNSEEEIIGDHTGSYKISESSEADESVVEEEEPSGETLNTEESEMGEEEESAEL | ||||||
Compositional bias | 1202-1230 | Polar residues | ||||
Sequence: SETCADELVEEVQTSSGDNSKSYETSEAN | ||||||
Compositional bias | 1241-1301 | Basic and acidic residues | ||||
Sequence: EGEYREGKNTSDKVSESNETHSEEFAEEEKPSGDKSESYEISEASETHTDNSEEEIIGDHT | ||||||
Compositional bias | 1313-1343 | Acidic residues | ||||
Sequence: DESVVEEEEPSGETLNTEESEMGEEEESAEL | ||||||
Repeat | 1402-1435 | TPR 2 | ||||
Sequence: YNLLVLSGKQSLAEGRKQEALDFFLKAIDINTGD |
Sequence similarities
Belongs to the SNF2/RAD54 helicase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,451
- Mass (Da)163,227
- Last updated2007-02-20 v1
- Checksum4BE27ACF410D1EDB
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M3AS17 | A0A8M3AS17_DANRE | ercc6l | 1428 |
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 45 | in Ref. 2; AAI50169 | ||||
Sequence: R → H | ||||||
Sequence conflict | 157 | in Ref. 2; AAI50169 | ||||
Sequence: T → A | ||||||
Compositional bias | 648-665 | Polar residues | ||||
Sequence: TRSSSTQQQLQAMHAQSR | ||||||
Compositional bias | 781-804 | Acidic residues | ||||
Sequence: DEPEFEEDEQNLPSAEDAEMETAS | ||||||
Compositional bias | 947-980 | Polar residues | ||||
Sequence: NTESKQQNSSQRFQSPSLQFPKLDDLSGASNTLG | ||||||
Compositional bias | 1107-1121 | Basic and acidic residues | ||||
Sequence: FVHSVRTKKRQVISD | ||||||
Compositional bias | 1202-1230 | Polar residues | ||||
Sequence: SETCADELVEEVQTSSGDNSKSYETSEAN | ||||||
Compositional bias | 1241-1301 | Basic and acidic residues | ||||
Sequence: EGEYREGKNTSDKVSESNETHSEEFAEEEKPSGDKSESYEISEASETHTDNSEEEIIGDHT | ||||||
Compositional bias | 1313-1343 | Acidic residues | ||||
Sequence: DESVVEEEEPSGETLNTEESEMGEEEESAEL |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CR391924 EMBL· GenBank· DDBJ | CAM13192.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX510925 EMBL· GenBank· DDBJ | CAM13192.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX510925 EMBL· GenBank· DDBJ | CAM14199.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CR391924 EMBL· GenBank· DDBJ | CAM14199.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC150168 EMBL· GenBank· DDBJ | AAI50169.1 EMBL· GenBank· DDBJ | mRNA |