A2BGR3 · ERC6L_DANRE

Function

function

DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro).

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site131-138ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentkinetochore
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent chromatin remodeler activity
Molecular FunctionDNA binding
Molecular FunctionDNA translocase activity
Molecular Functionhelicase activity
Biological Processcell division
Biological Processintein-mediated protein splicing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA excision repair protein ERCC-6-like
  • EC number
  • Alternative names
    • ATP-dependent helicase ERCC6-like

Gene names

    • Name
      ercc6l
    • ORF names
      si:ch211-278b8.3

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    A2BGR3
  • Secondary accessions
    • A7E225

Proteomes

Organism-specific databases

Subcellular Location

Chromosome
Note: Localizes to kinetochores, inner centromeres and thin threads connecting separating chromosomes even during anaphase.

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00003288331-1451DNA excision repair protein ERCC-6-like
Modified residue961Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for repeat, domain, motif, region, compositional bias.

TypeIDPosition(s)Description
Repeat27-60TPR 1
Domain118-286Helicase ATP-binding
Motif237-240DEAH box
Domain479-639Helicase C-terminal
Region647-669Disordered
Compositional bias648-665Polar residues
Region778-804Disordered
Compositional bias781-804Acidic residues
Region935-1006Disordered
Compositional bias947-980Polar residues
Region1035-1054Disordered
Region1063-1083Disordered
Region1096-1140Disordered
Compositional bias1107-1121Basic and acidic residues
Region1182-1343Disordered
Compositional bias1202-1230Polar residues
Compositional bias1241-1301Basic and acidic residues
Compositional bias1313-1343Acidic residues
Repeat1402-1435TPR 2

Sequence similarities

Belongs to the SNF2/RAD54 helicase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,451
  • Mass (Da)
    163,227
  • Last updated
    2007-02-20 v1
  • Checksum
    4BE27ACF410D1EDB
MESNNVEEVTDKFGGCLSLDTEKMGKYDRYRQKGKEAALNGELPRALELFQLAYQLQPSEKLKKRIQAIQDLIQREDEEDEEEEEEFVNVNNSGLKLYKGLYDKLYDHQKEGVAFLYSLYRDGRKGGILADDMGLGKTIQVISFLSGMYDAELANHTLLVMPTSLIKNWVREFAKWTPGMRVKEFHGSSKTERNRNLERIQRKGGVIITTYQMLINNYEQLGSNGHREFKWDYVILDEAHKIKTSSTKTAKSAHAIPAKNRVLLTGTPVQNNLREMWALFDFACQGSLLGTSKTFKTEYENPITRAREKDATPGEKALGLRISQNLTDIIKPYFLRRTKADVQQKKLKLEEGFEEEEDQENKCPNAREGVEMPSLTRKNDLIVWTYLSSVQEDIYNKFISLDQIKELLTTTRSPLAELTVLKKLCDHPRLLSQRAVIQLGLERGSDSELVHSDESESAVSQIDNISDHTLIEESGKLQFVVSLMECLREEGHRTLIFSQSRKMLDIMERVLRNRNFRLLRLDGTVTQLAEREKRISLFQTDKRYTIFLLTTQVGGVGITLTGANRVVIFDPSWNPATDAQAVDRAYRIGQTENVIIYRLITCGTVEEKIYRRQVFKDSLIRQTTGDKKNPFRYFSKQELRELFKLEDTRSSSTQQQLQAMHAQSRRSDTSLDHHIARLHSMEMFGISDHDLMFTKEPAADEDDPEDAESHHYIQTRVQKAQELMQAESELHGQLLDSMAQNTEPAWLRQMGQPNSSIRDRPAPPRIKNEPVTVDLTHNSFDEPEFEEDEQNLPSAEDAEMETASEDVEVIGDEDLGDKVISSEVEVVGEEVEVVAEEVEDAGEVEVVSEEVEGVGVEVEDVGVEVEDAGVEVEDAGVEVEDAGVEVEDAGEVEVVSGEGQVQPKSPQSGGEWNLQIVKTEVSPIAEKFADVITLDDTSDEADSSDFNTESKQQNSSQRFQSPSLQFPKLDDLSGASNTLGNEEVEPEKCHSQVLSSPLSQHEATTDEPFKAEMEMPHGNFNLLLEDSADMYFPEDEEVHEVEESAAEESPEFQLQMDVSGERLEEPSINHDKQNNGEFVNYNDSEVSKRESLLKIRSTPNESVDDSFVHSVRTKKRQVISDTEEEEEEEEESEKPCLTSSPFIDAISRLGSSTPKAVLVDGARLRRSLNASVASRRSFVVSLLENESDEESNEDKTKSSGASETCADELVEEVQTSSGDNSKSYETSEANGTLADELVEEEGEYREGKNTSDKVSESNETHSEEFAEEEKPSGDKSESYEISEASETHTDNSEEEIIGDHTGSYKISESSEADESVVEEEEPSGETLNTEESEMGEEEESAELIAGQEQEEWHSAVLESTGDVELDSNETMDQCAPKTVPVETHVLPVSSTNTAAEASDNKYNLLVLSGKQSLAEGRKQEALDFFLKAIDINTGDPEIQLLIIQLYRQLSQ

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8M3AS17A0A8M3AS17_DANREercc6l1428

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict45in Ref. 2; AAI50169
Sequence conflict157in Ref. 2; AAI50169
Compositional bias648-665Polar residues
Compositional bias781-804Acidic residues
Compositional bias947-980Polar residues
Compositional bias1107-1121Basic and acidic residues
Compositional bias1202-1230Polar residues
Compositional bias1241-1301Basic and acidic residues
Compositional bias1313-1343Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CR391924
EMBL· GenBank· DDBJ
CAM13192.1
EMBL· GenBank· DDBJ
Genomic DNA
BX510925
EMBL· GenBank· DDBJ
CAM13192.1
EMBL· GenBank· DDBJ
Genomic DNA
BX510925
EMBL· GenBank· DDBJ
CAM14199.1
EMBL· GenBank· DDBJ
Genomic DNA
CR391924
EMBL· GenBank· DDBJ
CAM14199.1
EMBL· GenBank· DDBJ
Genomic DNA
BC150168
EMBL· GenBank· DDBJ
AAI50169.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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