A2BGM5 · FOXN4_DANRE

Function

function

Transcription factor essential for neural and some non-neural tissues development. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates. Drives commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal.

Features

Showing features for dna binding.

155050100150200250300350400450500550
TypeIDPosition(s)Description
DNA binding231-327Fork-head

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular Functionchromatin binding
Molecular Functioncis-regulatory region sequence-specific DNA binding
Molecular FunctionDNA-binding transcription factor activity
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Functionsequence-specific DNA binding
Biological Processamacrine cell differentiation
Biological Processatrioventricular canal development
Biological Processheart looping
Biological Processheart valve development
Biological Processpositive regulation of DNA-templated transcription
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processregulation of DNA-templated transcription
Biological Processregulation of heart contraction
Biological Processretina layer formation
Biological Processventral spinal cord interneuron fate commitment

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Forkhead box protein N4

Gene names

    • Name
      foxn4
    • Synonyms
      sli, slipjig

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    A2BGM5
  • Secondary accessions
    • Q8UVH2
    • Q90X68
    • Q9DG30
    • Q9PT94

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

At 36-48 hpf, mutants exhibit pericardial edema due to dysmorphic hearts that fail to loop and form and atrioventricular (AV) canal. Hearts show continues peristatic pumping rather than coordinated and sequential beating of atrial and ventricular chambers. Endocardial cells remain squamous and AV myocardial cell shape fail to occur.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004289071-550Forkhead box protein N4

Proteomic databases

Expression

Tissue specificity

Isoform 1 is expressed mainly in adult thymus. Isoform 2 is detected in adult skin. Isoform 3 is expressed in adult brain and embryo. Prominent expression sites include the olfactory placode, the basal layer of the olfactory epithelium, the neuroepithelium of the developing retina, the germinal zone of the differentiated eye, regions of motoneuron development in the neural tube and periventricular regions of the brain.

Developmental stage

In embryo, expressed ubiquitously, but with decreasing intensity, from the one-cell through gastrula stages.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region402-437Disordered
Compositional bias422-437Polar residues

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative promoter usage.

A2BGM5-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    550
  • Mass (Da)
    60,968
  • Last updated
    2007-02-20 v1
  • Checksum
    D030E6C2022B33C0
MTVQSKLQGRGKFKKRFFRAGQQVPRPTLELSSVWLSKIFYNPEQHHNKQKMIESGITTRMSGIHENPGQSHHTSAQDYRLLTTDPSQLKDELPGDLQSLSWLTSVDVPRLQQIGGGRPDFTSSAQSSLLERQTAQLNSMTVAGGAGSAIHLQSEMQHSPLAINSMPQFSPGFPCAASVYQTAPQQVLTFTQANQQCSPGGLYGNYNSQNLFPQPRITAHSQDLQPKCFPKPIYSYSCLIAMALKNSKTGSLPVSEIYSFMKEHFPYFKTAPDGWKNSVRHNLSLNKCFEKVENKMSGSSRKGCLWALNPAKIDKMEEEMQKWKRKDLPAIRRSMANPDELDKLITDRPESCRQKSVDPGMTRLPSCPPGQTLPLAAQMQPQPVVTLSLQCLPMHQHLQLQLQNQSRLAPSSPAPAQTPPLHTVPDMTNSSLPQHPAKQHTDFYTVHTDVNSEVDALDPSIMDFAWQGNLWEEMKDDSFNLEALGTLSNSPLRLSDCDLDTSSVTPVSSAGGLPYPDLQVTGLYSSYSAIDALSNQYMNTQGGTKPIVLL

A2BGM5-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-134: MTVQSKLQGRGKFKKRFFRAGQQVPRPTLELSSVWLSKIFYNPEQHHNKQKMIESGITTRMSGIHENPGQSHHTSAQDYRLLTTDPSQLKDELPGDLQSLSWLTSVDVPRLQQIGGGRPDFTSSAQSSLLERQT → MAP

A2BGM5-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8M2BC99A0A8M2BC99_DANREfoxn4549

Features

Showing features for alternative sequence, sequence conflict, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0543271-134in isoform 2
Alternative sequenceVSP_0543261-139in isoform 3
Sequence conflict8in Ref. 1; CAB64948, 2; AAG27086 and 4; AAI28812
Sequence conflict39in Ref. 1; CAB64948
Compositional bias422-437Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ252024
EMBL· GenBank· DDBJ
CAB64948.1
EMBL· GenBank· DDBJ
mRNA
AF198446
EMBL· GenBank· DDBJ
AAG27086.2
EMBL· GenBank· DDBJ
mRNA
AF424786
EMBL· GenBank· DDBJ
AAL17865.1
EMBL· GenBank· DDBJ
mRNA
AF443870
EMBL· GenBank· DDBJ
AAL38028.1
EMBL· GenBank· DDBJ
mRNA
BX510366
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BX510917
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC128811
EMBL· GenBank· DDBJ
AAI28812.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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