A2AMS3 · A2AMS3_MOUSE
- ProteinGalactose-1-phosphate uridylyltransferase
- GeneGalt
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids360 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 Fe cation per subunit.
Pathway
Carbohydrate metabolism; galactose metabolism.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 29-32 | UDP-alpha-D-glucose (UniProtKB | ChEBI); ligand shared between dimeric partners | |||
Binding site | 62 | UDP-alpha-D-glucose (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain | |||
Binding site | 78-79 | UDP-alpha-D-glucose (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain | |||
Binding site | 154 | UDP-alpha-D-glucose (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain | |||
Binding site | 160-162 | UDP-alpha-D-glucose (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain | |||
Active site | 167 | Tele-UMP-histidine intermediate | |||
Binding site | 169 | UDP-alpha-D-glucose (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain | |||
Binding site | 183 | Fe cation (UniProtKB | ChEBI) | |||
Binding site | 282 | Fe cation (UniProtKB | ChEBI) | |||
Binding site | 300 | Fe cation (UniProtKB | ChEBI) | |||
Binding site | 302 | Fe cation (UniProtKB | ChEBI) | |||
Binding site | 315-316 | UDP-alpha-D-glucose (UniProtKB | ChEBI); ligand shared between dimeric partners | |||
Binding site | 320-321 | UDP-alpha-D-glucose (UniProtKB | ChEBI); ligand shared between dimeric partners | |||
Binding site | 327 | UDP-alpha-D-glucose (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | Golgi apparatus | |
Molecular Function | UDP-glucose:hexose-1-phosphate uridylyltransferase activity | |
Molecular Function | zinc ion binding | |
Biological Process | galactose metabolic process | |
Biological Process | UDP-glucose metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGalactose-1-phosphate uridylyltransferase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionA2AMS3
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 5-177 | Galactose-1-phosphate uridyl transferase N-terminal | |||
Domain | 184-349 | Galactose-1-phosphate uridyl transferase C-terminal | |||
Sequence similarities
Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length360
- Mass (Da)41,235
- Last updated2022-12-14 v3
- MD5 Checksum88D5E77D410989C4D5D52B35BE95C919
Computationally mapped potential isoform sequences
There are 8 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q03249 | GALT_MOUSE | Galt | 379 | ||
Q3TQJ2 | Q3TQJ2_MOUSE | Galt | 203 | ||
A2AMS2 | A2AMS2_MOUSE | Galt | 356 | ||
A0A8V5L185 | A0A8V5L185_MOUSE | Galt | 188 | ||
A0A8V5L0N9 | A0A8V5L0N9_MOUSE | Galt | 225 | ||
A0A8V5KY85 | A0A8V5KY85_MOUSE | Galt | 36 | ||
A0A8V5KX58 | A0A8V5KX58_MOUSE | Galt | 65 | ||
A0A8V5KX60 | A0A8V5KX60_MOUSE | Galt | 173 |
Keywords
- Technical term