A2AFR3 · FRPD4_MOUSE
- ProteinFERM and PDZ domain-containing protein 4
- GeneFrmpd4
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1320 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoskeleton | |
Cellular Component | dendritic spine | |
Cellular Component | glutamatergic synapse | |
Cellular Component | postsynaptic density | |
Molecular Function | phosphatidylinositol-4,5-bisphosphate binding | |
Biological Process | positive regulation of synapse structural plasticity | |
Biological Process | postsynaptic actin cytoskeleton organization |
Keywords
- Ligand
Names & Taxonomy
Protein names
- Recommended nameFERM and PDZ domain-containing protein 4
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionA2AFR3
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000307133 | 1-1320 | FERM and PDZ domain-containing protein 4 | |||
Sequence: MDVFSFVKIPKLSSHRTKSSGWPPPSGTWGLNQVPPYGWEMMTNRDGRDYFINHMTQAIPFDDPRFDSCQIIPPAPRKVEMRRDPVLGFGFVAGSEKPVVVRSVTPGGPSEGKLIPGDQIVMINDEAVSAAPRERVIDLVRSCKESILLTVIQPYPSPKSAFISAAKKARLKSNPVKVRFSEEVIINGQVSETVKDNSLLFMPNVLKVYLENGQTKSFRFDCSTSIKDVILTLQEKLSIKGIEHFSLMLEQRIEGAGTKLLLLHEQETLTQVTQRPSSHKMRCLFRISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERFGPELKYDIALRLAALQMYIATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMKEKNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRLYGGRVFKATLVQAEKRSEVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFTEEESLVRVELHVLDVKPITLLMESSDAMNLACLTAGYYRLLVDSRRSIFNMANKKNAGTQDTGSENKGKHNLLGPDWNCMPQMTTFIGEGEQEAQITYIDSKQKTVEMTDSTLCPKEHRHLYIDNSYSSDELNQPLTQPGDAPCEADYRSLAQRSLLTLSGPDTLKKAQESPRGAKVSFIFGDLALDDGMSPPTIGYERMLEENPEMLEKQRNLYISSANDMKNLDLTPDTDSIQFVANSVYANIGDVKNFEAPEGIEEPLLHDICYAENTDDAEDEDEVSCEEDLVVGEMNQPAILDLSGSSDDIIDLTTLPPPEGDDNEDDFLLRSLNMAIAAPPPGFRDSSDEEDTQSQATSFHEDKEQGSSLQNEEIPVSLIDAVPTSAEGKCEKGLDPAVVSTLEALEALSEEQQKSENSGVAILRAYSPESSSDSGNETNSSEMTEGSELAAAQKQSESLSRMFLATHEGYHPLAEEQTEFPTSKAPSVGLPPKSSHGLAARPATDLPPKVVPSKQILHSDHMEMEPETMETKSVTDYFSKLHMGSVAYSCTSKRKSKLPEGEGKSPLSGNIPGKKQQGTKIAEIEEDTKGKAGTVSSRDNPHLSTFNLERTAFRKDSQRWYVASDGGVVEKSGMEAPAMKVFPRGPGLGNREAEGKEDGTVEGGADDASVLGQGDRFLTDMACVASAKDLDNPEDTDSPSCDHATKLSEAEDNVARLCDYHLAKRMSSLQSEGHFSLQSSQGSSVDTGCGPGSSSSACATPVESPLCPSMGKHMIPDASGKGGRYISPEERAPGHPNHGATFEELHPQTEGMCPRMTVPALHTAINADPLFGTLRDGCHRLPKIKETTV |
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in various regions of the brain, including cortex, hippocampus, cerebellum, olfactory bulb and medial habenular nucleus.
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 33-66 | WW | ||||
Sequence: QVPPYGWEMMTNRDGRDYFINHMTQAIPFDDPRF | ||||||
Domain | 78-155 | PDZ | ||||
Sequence: KVEMRRDPVLGFGFVAGSEKPVVVRSVTPGGPSEGKLIPGDQIVMINDEAVSAAPRERVIDLVRSCKESILLTVIQPY | ||||||
Domain | 204-519 | FERM | ||||
Sequence: NVLKVYLENGQTKSFRFDCSTSIKDVILTLQEKLSIKGIEHFSLMLEQRIEGAGTKLLLLHEQETLTQVTQRPSSHKMRCLFRISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERFGPELKYDIALRLAALQMYIATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMKEKNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRLYGGRVFKATLVQAEKRSEVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFTEEESLVRVELHVLDVKPITLLMESSDAMNLACLTAGYYRLLVDSR | ||||||
Region | 809-847 | Disordered | ||||
Sequence: APPPGFRDSSDEEDTQSQATSFHEDKEQGSSLQNEEIPV | ||||||
Compositional bias | 815-829 | Basic and acidic residues | ||||
Sequence: RDSSDEEDTQSQATS | ||||||
Compositional bias | 830-845 | Polar residues | ||||
Sequence: FHEDKEQGSSLQNEEI | ||||||
Region | 897-927 | Disordered | ||||
Sequence: YSPESSSDSGNETNSSEMTEGSELAAAQKQS | ||||||
Region | 949-981 | Disordered | ||||
Sequence: TEFPTSKAPSVGLPPKSSHGLAARPATDLPPKV | ||||||
Region | 1024-1050 | Disordered | ||||
Sequence: KRKSKLPEGEGKSPLSGNIPGKKQQGT | ||||||
Region | 1114-1139 | Disordered | ||||
Sequence: PRGPGLGNREAEGKEDGTVEGGADDA | ||||||
Compositional bias | 1204-1233 | Polar residues | ||||
Sequence: GHFSLQSSQGSSVDTGCGPGSSSSACATPV | ||||||
Region | 1204-1274 | Disordered | ||||
Sequence: GHFSLQSSQGSSVDTGCGPGSSSSACATPVESPLCPSMGKHMIPDASGKGGRYISPEERAPGHPNHGATFE |
Domain
The FERM domain mediates the interaction with phosphatidylinositol 4,5-bisphosphate.
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
A2AFR3-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length1,320
- Mass (Da)144,978
- Last updated2007-02-20 v1
- ChecksumB8E9FE340BBF7475
A2AFR3-2
- Name2
- Differences from canonical
- 1-40: Missing
A2AFR3-3
- Name3
- Differences from canonical
- 1-14: MDVFSFVKIPKLSS → MRSHSC
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A589MR22 | A0A589MR22_MOUSE | Frmpd4 | 1760 | ||
A0A589MR67 | A0A589MR67_MOUSE | Frmpd4 | 37 | ||
A0A571BG68 | A0A571BG68_MOUSE | Frmpd4 | 1778 |
Sequence caution
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_028582 | 1-14 | in isoform 3 | |||
Sequence: MDVFSFVKIPKLSS → MRSHSC | ||||||
Alternative sequence | VSP_028581 | 1-40 | in isoform 2 | |||
Sequence: Missing | ||||||
Compositional bias | 815-829 | Basic and acidic residues | ||||
Sequence: RDSSDEEDTQSQATS | ||||||
Compositional bias | 830-845 | Polar residues | ||||
Sequence: FHEDKEQGSSLQNEEI | ||||||
Compositional bias | 1204-1233 | Polar residues | ||||
Sequence: GHFSLQSSQGSSVDTGCGPGSSSSACATPV |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK147370 EMBL· GenBank· DDBJ | BAE27868.1 EMBL· GenBank· DDBJ | mRNA | ||
AK147440 EMBL· GenBank· DDBJ | BAE27913.1 EMBL· GenBank· DDBJ | mRNA | ||
AL672186 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL807744 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL807773 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BX546498 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC139429 EMBL· GenBank· DDBJ | AAI39430.1 EMBL· GenBank· DDBJ | mRNA | ||
AK122244 EMBL· GenBank· DDBJ | BAC65526.1 EMBL· GenBank· DDBJ | Transcribed RNA | Sequence problems. |