We show that PTP-3 a LAR homolog in Caenorhabditis elegans participates in Sema2A-regulated axon guidance. PTPdelta a member of vertebrate LAR class PTPs is involved in Sema3A-regulated cortical dendritic growth. In Sema3A signaling PTPdelta activates Fyn and Src kinases by dephosphorylating their C-terminal Tyr residues.
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