A1ZA18 · A1ZA18_DROME
- ProteinKinesin heavy chain 73, isoform A
- GeneKhc-73
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1921 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | early endosome | |
Cellular Component | kinesin complex | |
Cellular Component | microtubule | |
Cellular Component | microtubule plus-end | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | microtubule binding | |
Molecular Function | microtubule motor activity | |
Molecular Function | protein homodimerization activity | |
Biological Process | cytoskeleton-dependent intracellular transport | |
Biological Process | establishment of spindle orientation | |
Biological Process | microtubule-based movement |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionA1ZA18
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Family & Domains
Features
Showing features for domain, coiled coil, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 5-352 | Kinesin motor | ||||
Sequence: KIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRI | ||||||
Coiled coil | 589-621 | |||||
Sequence: IARLERQHEEDKQVALEKQRQEYERQFQQLRNI | ||||||
Region | 770-789 | Disordered | ||||
Sequence: SEDEFDDKDEDNAKPQDPFY | ||||||
Region | 844-868 | Disordered | ||||
Sequence: QDRMCESVSESSGDSRDEYDDPVDP | ||||||
Compositional bias | 852-866 | Basic and acidic residues | ||||
Sequence: SESSGDSRDEYDDPV | ||||||
Region | 1475-1513 | Disordered | ||||
Sequence: EPLGGHRSLDEEPEDSYSDSEYAAEYEQERQQNKSMATR | ||||||
Region | 1591-1612 | Disordered | ||||
Sequence: ETPDFDRVNSNSPPNRQARVNP | ||||||
Compositional bias | 1593-1608 | Polar residues | ||||
Sequence: PDFDRVNSNSPPNRQA | ||||||
Compositional bias | 1643-1708 | Polar residues | ||||
Sequence: QLESSQNAQSDDDECAQLPKNNNNNLDLVNEPKPLSSQTDLEESMSQPKSKTEFATDNQNGNRSSD | ||||||
Region | 1643-1760 | Disordered | ||||
Sequence: QLESSQNAQSDDDECAQLPKNNNNNLDLVNEPKPLSSQTDLEESMSQPKSKTEFATDNQNGNRSSDELSHSSEDLLEGDGIVREELPAGKVVRRKKSNTQPPSNGNSINNNNNGTTQA | ||||||
Compositional bias | 1709-1734 | Basic and acidic residues | ||||
Sequence: ELSHSSEDLLEGDGIVREELPAGKVV | ||||||
Compositional bias | 1738-1760 | Polar residues | ||||
Sequence: KSNTQPPSNGNSINNNNNGTTQA | ||||||
Domain | 1826-1868 | CAP-Gly | ||||
Sequence: GTTEFQPGAWIGVELDTPTGKNDGSVKGVQYFQCKPKHGMFVR | ||||||
Region | 1887-1921 | Disordered | ||||
Sequence: AEKSNSISKEMSTSMTGSMTRSKSRGDSLNLSARK | ||||||
Compositional bias | 1891-1921 | Polar residues | ||||
Sequence: NSISKEMSTSMTGSMTRSKSRGDSLNLSARK |
Sequence similarities
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,921
- Mass (Da)214,998
- Last updated2007-02-06 v1
- ChecksumDEDCA75A63444C42
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0B4KFR5 | A0A0B4KFR5_DROME | Khc-73 | 1957 | ||
A0A0B4KG24 | A0A0B4KG24_DROME | Khc-73 | 1908 | ||
A0A0B4LGK5 | A0A0B4LGK5_DROME | Khc-73 | 1913 | ||
A4UZI0 | A4UZI0_DROME | Khc-73 | 1899 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 852-866 | Basic and acidic residues | ||||
Sequence: SESSGDSRDEYDDPV | ||||||
Compositional bias | 1593-1608 | Polar residues | ||||
Sequence: PDFDRVNSNSPPNRQA | ||||||
Compositional bias | 1643-1708 | Polar residues | ||||
Sequence: QLESSQNAQSDDDECAQLPKNNNNNLDLVNEPKPLSSQTDLEESMSQPKSKTEFATDNQNGNRSSD | ||||||
Compositional bias | 1709-1734 | Basic and acidic residues | ||||
Sequence: ELSHSSEDLLEGDGIVREELPAGKVV | ||||||
Compositional bias | 1738-1760 | Polar residues | ||||
Sequence: KSNTQPPSNGNSINNNNNGTTQA | ||||||
Compositional bias | 1891-1921 | Polar residues | ||||
Sequence: NSISKEMSTSMTGSMTRSKSRGDSLNLSARK |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE013599 EMBL· GenBank· DDBJ | AAM70975.1 EMBL· GenBank· DDBJ | Genomic DNA |