Drosophila centrosomin (cnn) expresses two major protein variants: the centrosomal form (CnnC) and a non-centrosomal form in testes (CnnT). CnnC is established as essential for functional centrosomes the major MTOCs in animal cells. CnnT is expressed exclusively in testes and localizes to giant mitochondria in spermatids.
The findings reveal that polarized targeting of Centrosomin to Golgi outposts during elaboration of the dendrite arbor creates a local system for guiding microtubule polymerization.
Cnn and PLP directly interact at two defined sites to coordinate the cell cycle-dependent rearrangement and scaffolding activity of the centrosome to permit normal centrosome organization cell division and embryonic viability.
Data indicate that interphase centrioles are closely associated with Sas-4 Spd-2 Polo kinase Pericentrin-like protein (Dplp) Asterless (Asl) Plk4 kinase Centrosomin (Cnn) and gamma-tubulin.
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