A1YBI7 · A1YBI7_9HEPC
- ProteinGenome polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids2403 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
function
Cysteine protease required for the proteolytic auto-cleavage between the non-structural proteins NS2 and NS3. The N-terminus of NS3 is required for the function of NS2 protease (active region NS2-3). Promotes the initiation of viral particle assembly by mediating the interaction between structural and non-structural proteins.
Induces a specific membrane alteration that serves as a scaffold for the virus replication complex. This membrane alteration gives rise to the so-called ER-derived membranous web that contains the replication complex. NS4B self-interaction contributes to its function in membranous web formation. Promotes host TRIF protein degradation in a CASP8-dependent manner thereby inhibiting host TLR3-mediated interferon signaling. Disrupts the interaction between STING and TBK1 contributing to the inhibition of interferon signaling.
RNA-dependent RNA polymerase that performs primer-template recognition and RNA synthesis during viral replication. Initiates RNA transcription/replication at a flavin adenine dinucleotide (FAD), resulting in a 5'- FAD cap on viral RNAs. In this way, recognition of viral 5' RNA by host pattern recognition receptors can be bypassed, thereby evading activation of antiviral pathways.
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
Cofactor
Protein has several cofactor binding sites:
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Hepacivirus
Accessions
- Primary accessionA1YBI7
Subcellular Location
UniProt Annotation
GO Annotation
Host endoplasmic reticulum membrane ; Multi-pass membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 184-206 | Helical | |||
Transmembrane | 218-243 | Helical | |||
Transmembrane | 249-268 | Helical | |||
Transmembrane | 280-301 | Helical | |||
Transmembrane | 1126-1154 | Helical | |||
Transmembrane | 1282-1306 | Helical | |||
Transmembrane | 1313-1336 | Helical | |||
Transmembrane | 1348-1368 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 365-492 | Peptidase C18 | |||
Domain | 493-674 | Peptidase S29 | |||
Domain | 683-835 | Helicase ATP-binding | |||
Domain | 827-1004 | Helicase C-terminal | |||
Compositional bias | 1818-1840 | Polar residues | |||
Region | 1818-1874 | Disordered | |||
Domain | 2100-2218 | RdRp catalytic | |||
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length2,403
- Mass (Da)261,058
- Last updated2007-02-06 v1
- MD5 ChecksumABDF2E93A5BBDAB64CF9DBFF73E99613
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Compositional bias | 1818-1840 | Polar residues | |||
Non-terminal residue | 2403 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DQ889290 EMBL· GenBank· DDBJ | ABK20236.1 EMBL· GenBank· DDBJ | Genomic RNA |