A1Y2M5 · A1Y2M5_9TRYP

  • Protein
    UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Protein modification; protein glycosylation.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionglycosyltransferase activity
Molecular FunctionUDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity
Biological Processdolichol-linked oligosaccharide biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
  • EC number
  • Alternative names
    • GlcNAc-1-P transferase
    • N-acetylglucosamine-1-phosphate transferase

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • LS-94
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leishmania > Leishmania guyanensis species complex

Accessions

  • Primary accession
    A1Y2M5

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-25Helical
Transmembrane80-102Helical
Transmembrane114-132Helical
Transmembrane144-166Helical
Transmembrane226-246Helical
Transmembrane309-327Helical
Transmembrane339-365Helical

Keywords

Family & Domains

Sequence similarities

Belongs to the glycosyltransferase 4 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    441
  • Mass (Da)
    48,363
  • Last updated
    2007-02-06 v1
  • MD5 Checksum
    7008723BCD16E035EDC08E1ACB12866B
CVAVAAHAPVLGLILLGSVVAYVGTTRYTPKVARKLFERDIFGIDINKTTAEQRQQFAARRRAGQTEEKEFQKQAIPESLGILVGAVYLSVVMALMFCLRFLGAVGDGTENVYASLPGPLMTITVMLLLGFVDDVLDVKWRHKIILTTLGSLPLIMTYDGSLSVLMPRVFGRFGLPTMNATKEWLLSLAAAQGEPPTAFRVTAPSTWFSYAVNHCAYVDVSDSGAALVYLGPLYLVYLSMLCIFCTNSINILAGVNGVEVGQSIVIAIASVVYNLCQMRLEGQVTPDWSNTDTAVAAVRDMSSDHQLRALLLLGPFIGASLALWHYNRYPARVFVGDSYTYFAGTVLAVSSITGVYSKTLLLFFAPQVFNFIISLPQLFGIVPCPRHRVPTWNPQTNLLSSSHNYTILNVILYVFGDMHEEKLTWAILKCQTIACVFGFVV

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue441

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ836163
EMBL· GenBank· DDBJ
ABI17925.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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