A1WWE4 · MNME_HALHL

Function

function

Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm5s2U34.

Cofactor

K+ (UniProtKB | Rhea| CHEBI:29103 )

Note: Binds 1 potassium ion per subunit.

Features

Showing features for binding site.

146950100150200250300350400450
TypeIDPosition(s)Description
Binding site38(6S)-5-formyl-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site95(6S)-5-formyl-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site134(6S)-5-formyl-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site240-245GTP (UniProtKB | ChEBI)
Binding site244Mg2+ (UniProtKB | ChEBI)
Binding site259-265GTP (UniProtKB | ChEBI)
Binding site265Mg2+ (UniProtKB | ChEBI)
Binding site284-287GTP (UniProtKB | ChEBI)
Binding site468(6S)-5-formyl-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionmetal ion binding
Biological ProcesstRNA methylation
Biological ProcesstRNA wobble uridine modification

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA modification GTPase MnmE
  • EC number

Gene names

    • Name
      mnmE
    • Synonyms
      trmE
    • Ordered locus names
      Hhal_1231

Organism names

Accessions

  • Primary accession
    A1WWE4

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003457971-469tRNA modification GTPase MnmE

Interaction

Subunit

Homodimer. Heterotetramer of two MnmE and two MnmG subunits.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain230-392TrmE-type G

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    469
  • Mass (Da)
    49,183
  • Last updated
    2007-02-06 v1
  • Checksum
    558FEA211E1A5C27
MVHTASGREVRHGLEDDDADTICAMATPSGQGGVAVVRVSGSRALEVAEEVAGPLPAPREAGLRRFRDARGETLDHGLVLVFPGPGSYTGEDVVELQGHGSPAAVTAVLEALCAAGARPAGPGEFSERAFLNGRLDLTQAEAVASLIEAETDGARRAALRALSGAFGQRVDGLADRMIDLRALIEAFLDFPEDEDVPADPPELAAEIEALGSELAEIRRRAAAGVRFGEGIRVALVGPPNAGKSSLLNVLSGEEAAIVSAQAGTTRDVVRQWAALGSRHAELLDTAGLRDAEAQDEIEAEGARRARAAASEADLLLVVIEAGKTLDEELRARIAEQAPRPVVVIVNKIDASGDEAGWEGESEVGAHVRRARVSAHTGAGIEALRRGLAALVDREAGEDAWAARHRHIEALDRAGEELEEALVVARRGGQEELVAEALRRAQTALGEITGRVSHEALLGRIFSGFCIGKE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000544
EMBL· GenBank· DDBJ
ABM62006.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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