A1U3I4 · PURT_MARN8

Function

function

Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide from N1-(5-phospho-D-ribosyl)glycinamide (formate route): step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site19-20N1-(5-phospho-beta-D-ribosyl)glycinamide (UniProtKB | ChEBI)
Binding site79N1-(5-phospho-beta-D-ribosyl)glycinamide (UniProtKB | ChEBI)
Binding site111ATP (UniProtKB | ChEBI)
Binding site152ATP (UniProtKB | ChEBI)
Binding site157-162ATP (UniProtKB | ChEBI)
Binding site192-195ATP (UniProtKB | ChEBI)
Binding site200ATP (UniProtKB | ChEBI)
Binding site264Mg2+ (UniProtKB | ChEBI)
Binding site276Mg2+ (UniProtKB | ChEBI)
Binding site283N1-(5-phospho-beta-D-ribosyl)glycinamide (UniProtKB | ChEBI)
Binding site353N1-(5-phospho-beta-D-ribosyl)glycinamide (UniProtKB | ChEBI)
Binding site360-361N1-(5-phospho-beta-D-ribosyl)glycinamide (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionligase activity
Molecular Functionmagnesium ion binding
Molecular Functionphosphoribosylglycinamide formyltransferase 2 activity
Molecular Functionphosphoribosylglycinamide formyltransferase activity
Biological Process'de novo' IMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Formate-dependent phosphoribosylglycinamide formyltransferase
  • EC number
  • Alternative names
    • 5'-phosphoribosylglycinamide transformylase 2
    • Formate-dependent GAR transformylase
    • GAR transformylase 2
      (GART 2
      )
    • Non-folate glycinamide ribonucleotide transformylase
    • Phosphoribosylglycinamide formyltransferase 2

Gene names

    • Name
      purT
    • Ordered locus names
      Maqu_2478

Organism names

Accessions

  • Primary accession
    A1U3I4

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003191851-390Formate-dependent phosphoribosylglycinamide formyltransferase

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain116-305ATP-grasp

Sequence similarities

Belongs to the PurK/PurT family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    390
  • Mass (Da)
    42,705
  • Last updated
    2008-02-26 v2
  • Checksum
    17718B43115E34C2
MGTPLKSNSFRVLFCGSGELGKEVVIELQRFGVEVIAIDRYADAPAMQVAHRSHVVDMLDPVALRSVIEKERPNLIVPEIEAIATPELVKLEQEGYRVIPSARAVNLTMNREGIRRLAAEELGLPTSPYRFAGTREEYLQAVAEVGLPLVVKPVMSSSGKGQSTVKTEADIERAWEYAQTGGRAGKGRVIVEGFVDFDYEITLLTVRHKEGITFCEPIGHRQEDGDYRESWQPQPMNDLALQRSKEIARAVVEDLGGYGIYGVELFVKGENVWFSEVSPRPHDTGLVTLVSQDLSEFAIHARAILGIPVPVVRQNGPSASAVILPEGSSTEVSYTGLEEALAQPGTQLRLFGKPELQGRRRMGVALALGSSIEDAREKARTAASSIKVQF

Sequence caution

The sequence ABM19553.1 differs from that shown. Reason: Erroneous initiation

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000514
EMBL· GenBank· DDBJ
ABM19553.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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