A1SGA2 · RNPH_NOCSJ
- ProteinRibonuclease PH
- Generph
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids242 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
Catalytic activity
- tRNA(n+1) + phosphate = tRNA(n) + a ribonucleoside 5'-diphosphate
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 3'-5'-RNA exonuclease activity | |
Molecular Function | tRNA binding | |
Molecular Function | tRNA nucleotidyltransferase activity | |
Biological Process | rRNA catabolic process | |
Biological Process | rRNA processing | |
Biological Process | tRNA processing |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRibonuclease PH
- EC number
- Short namesRNase PH
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Propionibacteriales > Nocardioidaceae > Nocardioides
Accessions
- Primary accessionA1SGA2
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000024844 | 1-242 | Ribonuclease PH | |||
Sequence: MSAAPREDGRADDELRPITITRHWLDHAAGSVLVEFGRTRVLCAASAAEGVPRWRKGSGLGWVTAEYAMLPASTNTRSDRESVKGRIGGRTHEISRLIGRSLRAIIDYKALGENTIQLDCDVLQADGGTRTAAITGAYVALADAVEHLRSTGALTGEPLTGSVAAVSVGIIDGVPRLDLPYVEDVRAETDMNVVMTGSGKFVEVQGTAEGAAFDRAELDALLALAEKGCADLTRLQQEALSR |
Interaction
Subunit
Homohexameric ring arranged as a trimer of dimers.
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length242
- Mass (Da)25,671
- Last updated2007-02-06 v1
- Checksum3DB016DF38CE9B8C
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000509 EMBL· GenBank· DDBJ | ABL80837.1 EMBL· GenBank· DDBJ | Genomic DNA |