A1RVD1 · AROC_PYRIL
- ProteinChorismate synthase
- GenearoC
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids365 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
Catalytic activity
- 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate
Cofactor
Note: Reduced FMN (FMNH2).
Pathway
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 46 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 124-126 | FMN (UniProtKB | ChEBI) | |||
Binding site | 284 | FMN (UniProtKB | ChEBI) | |||
Binding site | 299-303 | FMN (UniProtKB | ChEBI) | |||
Binding site | 326 | FMN (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | chorismate synthase activity | |
Molecular Function | FMN binding | |
Biological Process | amino acid biosynthetic process | |
Biological Process | aromatic amino acid family biosynthetic process | |
Biological Process | chorismate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameChorismate synthase
- EC number
- Short namesCS
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Thermoproteota > Thermoprotei > Thermoproteales > Thermoproteaceae > Pyrobaculum
Accessions
- Primary accessionA1RVD1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000322438 | 1-365 | Chorismate synthase | ||
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length365
- Mass (Da)39,614
- Last updated2007-02-06 v1
- ChecksumF43E9938A86807DB
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000504 EMBL· GenBank· DDBJ | ABL88913.1 EMBL· GenBank· DDBJ | Genomic DNA |