A1RTB8 · SUCC_PYRIL

Function

function

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site45ATP (UniProtKB | ChEBI)
Binding site52-54ATP (UniProtKB | ChEBI)
Binding site94ATP (UniProtKB | ChEBI)
Binding site99ATP (UniProtKB | ChEBI)
Binding site193Mg2+ (UniProtKB | ChEBI)
Binding site207Mg2+ (UniProtKB | ChEBI)
Binding site260substrate; ligand shared with subunit alpha
Binding site317-319substrate; ligand shared with subunit alpha

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmagnesium ion binding
Molecular Functionsuccinate-CoA ligase (ADP-forming) activity
Molecular Functionsuccinate-CoA ligase (GDP-forming) activity
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Succinate--CoA ligase [ADP-forming] subunit beta
  • EC number
  • Alternative names
    • Succinyl-CoA synthetase subunit beta
      (SCS-beta
      )

Gene names

    • Name
      sucC
    • Ordered locus names
      Pisl_1026

Organism names

Accessions

  • Primary accession
    A1RTB8

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000821821-382Succinate--CoA ligase [ADP-forming] subunit beta

Interaction

Subunit

Heterotetramer of two alpha and two beta subunits.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-240ATP-grasp

Sequence similarities

Belongs to the succinate/malate CoA ligase beta subunit family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    382
  • Mass (Da)
    42,355
  • Last updated
    2007-02-06 v1
  • Checksum
    06E2854D9DBA68B9
MKLHEYEAKELFLRYGVKIPPGKLALTPDEVRKIAEEIGTPVVLKAQVVVAGRGKAGGIKIAQTPEEAYELSKKMFGMNIKGLVVRKLYVTKYVEVEREMYLSLIIDRASRRYLFLASPIGGVDIEEIAKTSPEKIKKVYVDPSIGLRDYHIRSIISWLGFKPGSQQWQQTASVIQAMYRIMVDYDAELVETNPLALSKEGEVIPLDARVIVDDNALFKHPDLEKALEEDPRDITEFEAYAKKIGFHYVELDGDIGIIGNGAGLTMATMDLVYHFGGRPANFLDIGGGASREVVKEAVKVLLNHPRVKVIFVNIFGGITRADEVALGIKDALAEVKEHTKKIVVRIKGTNEEQGKAILSEIGIPLFENAEEAAKKAVELAKI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000504
EMBL· GenBank· DDBJ
ABL88200.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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