A1RST9 · A1RST9_PYRIL

Function

function

Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

Catalytic activity

  • ATP-dependent breakage, passage and rejoining of double-stranded DNA.
    EC:5.6.2.2 (UniProtKB | ENZYME | Rhea)

Features

Showing features for binding site.

152850100150200250300350400450500
TypeIDPosition(s)Description
Binding site42ATP (UniProtKB | ChEBI)
Binding site76ATP (UniProtKB | ChEBI)
Binding site97-98ATP (UniProtKB | ChEBI)
Binding site106-113ATP (UniProtKB | ChEBI)
Binding site424ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
Biological ProcessDNA topological change
Biological ProcessDNA unwinding involved in DNA replication

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Type 2 DNA topoisomerase 6 subunit B
  • EC number
  • Alternative names
    • Type II DNA topoisomerase VI subunit B
      (TopoVI-B
      )

Gene names

    • Name
      top6B
    • Ordered locus names
      Pisl_0845

Organism names

Accessions

  • Primary accession
    A1RST9

Proteomes

Interaction

Subunit

Homodimer. Heterotetramer of two Top6A and two Top6B chains.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain27-142Histidine kinase/HSP90-like ATPase

Sequence similarities

Belongs to the TOP6B family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    528
  • Mass (Da)
    60,269
  • Last updated
    2007-02-06 v1
  • Checksum
    546368D5B4E04289
MSSIYSYEALPVAEWFRRNRELAGFHNPARALYQTIRELVENSLDATETYGILPNIYIRVSIEDEQKGWASVYVEDNGIGIPGNEIPNVFGRVFYSSKYKIKQHRGVFGLGLKMVVLYSQSTTNKPVYVRSSTIKSDKIYEYQIMIDTNNNSPIILDRREYPNKYKWHGTAVKVYLEGNWPAAKKRIEDYLKRTAIIAPYAEIILKSPDLELWLKRRTTKLPPPPKEGLPHPKSVDVDTVKQMLLESRNMSLLEFLTENFDAVGEGTAKAFLEWAGFNPNTKTTALTPEEIVRLVEKMKQYEGWRRPRADWLSPVGSELLEIGAKAILGAEAVFAVTRKPESYSGHPFIVEVAVAWGGQIPPVDKPLLLRYANKIPLLYDEGADVARKIVDEFNWQNYKIKFPAPLAVITHICSTKIPYASAGKEAIAEVPEIEKEIRLALRDVAKKLRLYLSRKEKEMELLNKYISLAKYVDEIAHNLSIITRLDREPLEKNLYKLIEKKIGLTIDELIKHTLSTQLTQQEETIAAA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000504
EMBL· GenBank· DDBJ
ABL88021.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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