A1RQJ4 · A1RQJ4_PYRIL
- ProteinDelta-aminolevulinic acid dehydratase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids336 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Catalytic activity
- 2 5-aminolevulinate = porphobilinogen + 2 H2O + H+
Pathway
Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 123 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 125 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 133 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Active site | 202 | Schiff-base intermediate with substrate | |||
Binding site | 212 | 5-aminolevulinate 1 (UniProtKB | ChEBI) | |||
Binding site | 224 | 5-aminolevulinate 1 (UniProtKB | ChEBI) | |||
Binding site | 240 | Mg2+ (UniProtKB | ChEBI) | |||
Active site | 255 | Schiff-base intermediate with substrate | |||
Binding site | 282 | 5-aminolevulinate 2 (UniProtKB | ChEBI) | |||
Binding site | 321 | 5-aminolevulinate 2 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | porphobilinogen synthase activity | |
Molecular Function | zinc ion binding | |
Biological Process | protoporphyrinogen IX biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDelta-aminolevulinic acid dehydratase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Thermoproteota > Thermoprotei > Thermoproteales > Thermoproteaceae > Pyrobaculum
Accessions
- Primary accessionA1RQJ4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Structure
Sequence
- Sequence statusComplete
- Length336
- Mass (Da)37,077
- Last updated2007-02-06 v1
- MD5 ChecksumBA0A26E6A9422686CA360AFA50A5DF8B
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000504 EMBL· GenBank· DDBJ | ABL87226.1 EMBL· GenBank· DDBJ | Genomic DNA |