A1R7K0 · LEUC_PAEAT

Function

function

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit.

Pathway

Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site352[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site412[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site415[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function3-isopropylmalate dehydratase activity
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionmetal ion binding
Biological ProcessL-leucine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-isopropylmalate dehydratase large subunit
  • EC number
  • Alternative names
    • Alpha-IPM isomerase
      (IPMI
      )
    • Isopropylmalate isomerase

Gene names

    • Name
      leuC
    • Ordered locus names
      AAur_2486

Organism names

Accessions

  • Primary accession
    A1R7K0

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000635241-4833-isopropylmalate dehydratase large subunit

Interaction

Subunit

Heterodimer of LeuC and LeuD.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    483
  • Mass (Da)
    51,419
  • Last updated
    2007-02-06 v1
  • Checksum
    513CD42516998A99
MGKTLAEKVWDAHVVRKGEGEGANAQPDLLFIDLHLIHEVTSPQAFEGLRLAGRPLRRVDLTIATEDHNTPTLDIDKPIADLTSRTQIETLRANCKEFGVRLHSLGDKEQGIVHVVGPQLGLTQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVMATQTLSLKPFKTMAINVEGTLRPGVTAKDIILAVIAKIGTGGGQGYVLEYRGSAIRALSMDARMTICNMSIEAGARAGMVAPDQTTYDYMQGRPHAPEGADWDAAVEYWNTLTTDADATFDVEVDLDADTLEPFVTWGTNPGQGVSLSAKVPSPEDFGDENAKAAAERALQYMGLEAGTPMKDIRVDTVFLGSCTNSRIEDLRVAADIIRGRAKDPNVRMLVVPGSARVRLEAEAEGLDKVFKEFGAEWRFAGCSMCLGMNPDQLEPGERCASTSNRNFEGRQGKGGRTHLVSPVVAAATAVRGTLSSPSDLEPAAAGALTGIAV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000474
EMBL· GenBank· DDBJ
ABM10288.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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