A1R419 · A1R419_PAEAT
- ProteinN-acetylmuramic acid 6-phosphate etherase
- GenemurQ
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids319 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.
Miscellaneous
A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.
Catalytic activity
- N-acetyl-D-muramate 6-phosphate + H2O = N-acetyl-D-glucosamine 6-phosphate + (R)-lactate
Pathway
Amino-sugar metabolism; N-acetylmuramate degradation.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 103 | Proton donor | |||
Active site | 134 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | carbohydrate binding | |
Molecular Function | carbon-oxygen lyase activity | |
Molecular Function | enzyme binding | |
Molecular Function | enzyme inhibitor activity | |
Molecular Function | fructose-6-phosphate binding | |
Molecular Function | isomerase activity | |
Biological Process | amino sugar catabolic process | |
Biological Process | glucose homeostasis | |
Biological Process | N-acetylmuramic acid catabolic process | |
Biological Process | negative regulation of glucokinase activity | |
Biological Process | response to fructose |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameN-acetylmuramic acid 6-phosphate etherase
- EC number
- Short namesMurNAc-6-P etherase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Micrococcales > Micrococcaceae > Paenarthrobacter
Accessions
- Primary accessionA1R419
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length319
- Mass (Da)32,453
- Last updated2007-02-06 v1
- MD5 ChecksumBD0913E50B3E9FB276A9A8AE319FA106
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000474 EMBL· GenBank· DDBJ | ABM06496.1 EMBL· GenBank· DDBJ | Genomic DNA |