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A1R419 · A1R419_PAEAT

Function

function

Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.

Miscellaneous

A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.

Catalytic activity

Pathway

Amino-sugar metabolism; N-acetylmuramate degradation.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site103Proton donor
Active site134

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncarbohydrate binding
Molecular Functioncarbon-oxygen lyase activity
Molecular Functionenzyme binding
Molecular Functionenzyme inhibitor activity
Molecular Functionfructose-6-phosphate binding
Molecular Functionisomerase activity
Biological Processamino sugar catabolic process
Biological Processglucose homeostasis
Biological ProcessN-acetylmuramic acid catabolic process
Biological Processnegative regulation of glucokinase activity
Biological Processresponse to fructose

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    N-acetylmuramic acid 6-phosphate etherase
  • EC number
  • Short names
    MurNAc-6-P etherase
  • Alternative names
    • N-acetylmuramic acid 6-phosphate hydrolase
    • N-acetylmuramic acid 6-phosphate lyase

Gene names

    • Name
      murQ
    • Ordered locus names
      AAur_1195

Organism names

Accessions

  • Primary accession
    A1R419

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain75-238SIS

Sequence similarities

Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    319
  • Mass (Da)
    32,453
  • Last updated
    2007-02-06 v1
  • MD5 Checksum
    BD0913E50B3E9FB276A9A8AE319FA106
MTEQTGPTSPTDADKLAGLRTELAGLQTEATAGGLDNLDILGTEELVAAMLAHSAGVHAAVEAASPAIVQTVDAVAERLQRGGRLLYVGAGTAGRLGVLDASECPPTFGTPPGLVVGLIAGGVQAIQKPVEYAEDNATAGARDLHDINVTEADAVVGITASGRTPYVIGALEEARKRGAFTASLACNKGSAVSHLTDAAIEVVVGPEFIAGSTRLNSGTAQKLVLNMISTLVMVKLGKTYGNLMVDLRATNEKLLARSQRTVQHATGVSAQEAATALDSVGGSVKAAILVLLTGIEAGQAKGALEEAGGFLRRAIENQK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000474
EMBL· GenBank· DDBJ
ABM06496.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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