A1R3C9 · A1R3C9_PAEAT

Function

function

Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site36(6S)-NADPHX (UniProtKB | ChEBI)
Binding site107(6S)-NADPHX (UniProtKB | ChEBI)
Binding site233AMP (UniProtKB | ChEBI)
Binding site234(6S)-NADPHX (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionADP-dependent NAD(P)H-hydrate dehydratase activity
Molecular FunctionATP binding
Molecular Functionkinase activity
Molecular FunctionNADHX epimerase activity
Molecular FunctionNADPHX epimerase activity
Biological Processmetabolite repair
Biological Processnicotinamide nucleotide metabolic process
Biological Processphosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ADP-dependent (S)-NAD(P)H-hydrate dehydratase
  • EC number
  • Alternative names
    • ADP-dependent NAD(P)HX dehydratase

Gene names

    • Name
      nnrD
    • Ordered locus names
      AAur_0951

Organism names

Accessions

  • Primary accession
    A1R3C9

Proteomes

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-293YjeF C-terminal

Sequence similarities

Belongs to the NnrD/CARKD family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    295
  • Mass (Da)
    29,945
  • Last updated
    2007-02-06 v1
  • Checksum
    477CBC80020ECBCB
MTPSLLRDWPLPAPGDDKYSRGAVLVIGGARVTPGAALLAGISALRAGAGKITLAVAESVAVQVGVALPECGALGLPENASGSLTGEGLDRISSYLERADAMLIGPGLDDLELAESLLRTLLEREESHAAPGTEGGPAVVLDAFALGGLVKVEDVLEPWRGRLILTPNPTETGILLGRDVGDLGADVAEVARRFDAVVSCQGYIAGPGAETADDSTLWKITTGYGGLGTSGSGDVLAGAIAGLRARGTSDAQAACWGTHLHAAAADRLASKLGPLGFLARELADELPALMLELNT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000474
EMBL· GenBank· DDBJ
ABM07592.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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