A1L3G9 · NMP1B_XENLA

Function

function

In concert with ran, required for proper eye development (PubMed:25946333).
May be involved in the expression of early eye marker genes (PubMed:19167377).
Contributes to nuclear envelope stiffness in germ cells (By similarity).
Required for fertility (By similarity).
Essential for normal erythropoiesis (By similarity).
Required for efficient nuclear envelope opening and enucleation during the late stages of erythroblast maturation (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnuclear envelope
Cellular Componentnuclear inner membrane
Biological Processerythrocyte enucleation
Biological Processerythrocyte maturation
Biological Processeye development

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Nuclear envelope integral membrane protein 1b

Gene names

    • Name
      nemp1b
    • Synonyms
      tmem194a-b

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus

Accessions

  • Primary accession
    A1L3G9
  • Secondary accessions
    • B9X188

Proteomes

Organism-specific databases

Subcellular Location

Nucleus inner membrane
; Multi-pass membrane protein
Nucleus envelope
Note: Localization in the nuclear membrane is essential for its function. Colocalizes with lamins and banf1-a/b at the nuclear envelope.

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane151-171Helical
Transmembrane175-195Helical
Transmembrane206-226Helical
Transmembrane239-259Helical
Transmembrane280-300Helical

Keywords

Phenotypes & Variants

Disruption phenotype

Morpholino knockdown results in defects in eye development, reduced expression of early eye marker genes rax, tbx3, six3 and pax6 and reduction of cell density at the neurula stage. Co-knockdown of nemp1b and ran elicits reduction of cell density and eye defects more significantly than the individual knockdown of either one.

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-29
ChainPRO_000033224130-434Nuclear envelope integral membrane protein 1b

Post-translational modification

Phosphorylated.

Expression

Developmental stage

Expressed both maternally and zygotically. At the early gastrula stage, expressed mainly in the entire animal hemisphere. During neurulation, its expression becomes restricted to the anterior neuroectoderm. At the tailbud stage, expressed in various anterior regions including the anterior central nervous system (CNS), otic vesicles, and branchial arches.

Gene expression databases

    • 100037004Expressed in egg cell and 18 other cell types or tissues

Interaction

Subunit

Interacts with banf1-a and banf1-b. Interacts with ran-gtp.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, motif.

TypeIDPosition(s)Description
Region176-287A; required for its colocalization with lamins at the nuclear envelope
Motif317-325Nuclear localization signal
Region326-395B; interaction with ran
Region326-434Interaction with banf1-a and banf1-b
Region368-375BAF-binding site (BBS); essential for interaction with banf1-a, banf1-b and ran

Domain

The transmembrane domains are required and sufficient for its oligomerization.

Sequence similarities

Belongs to the NEMP family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    434
  • Mass (Da)
    50,327
  • Last updated
    2007-02-06 v1
  • Checksum
    258089C9B16BA011
MAGEVEGRGCGFSLGVLVTLLVLPLPSLCTLSTEKELHVIKLYEGRMVRYNESRNFCYQRTYEPKWSDVWTKIQIRINSTKMIRVTQVDNEEKLKEMETFNMFDFFSSFLKEKLNDTFIYVNLYSNKTCVKVHLTDTDTYYSVALSRGFDPRLFFVFLCGLLLFFYGDTLSRSQLFFYSTGITVGMLASMLILVFMLSKLMPKKSPFFALLLGGWSVSIYVIQLVFRNLQAICSEYWQYLIVYLGIVGFVSFAFCYIYGPLENERSINILNWTLQLIGLLLMYVSVQIQHIAVTIVVIAFCTKQIEYPVQWIYILYRKIKLKRAKPGPPRLLTEEEYRKQADVETRKALEELRECCSSPDFAAWKTISRIQSPKRFADFVEGSSHLTPNEVSVHEHEYGLGGSFLEDELFGEDSDVEEEMEIEPPLYPIPRSVF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB474920
EMBL· GenBank· DDBJ
BAH24056.1
EMBL· GenBank· DDBJ
mRNA
BC130092
EMBL· GenBank· DDBJ
AAI30093.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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