A1L258 · D2HDH_DANRE

Function

function

Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate (By similarity).
Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC) (By similarity).
Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC (By similarity).

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site397(R)-2-hydroxyglutarate (UniProtKB | ChEBI)
Binding site397(R)-lactate (UniProtKB | ChEBI)
Binding site397(R)-malate (UniProtKB | ChEBI)
Binding site401(R)-2-hydroxyglutarate (UniProtKB | ChEBI)
Binding site401(R)-malate (UniProtKB | ChEBI)
Binding site412(R)-2-hydroxyglutarate (UniProtKB | ChEBI)
Binding site412(R)-malate (UniProtKB | ChEBI)
Binding site445Zn2+ (UniProtKB | ChEBI)
Binding site452Zn2+ (UniProtKB | ChEBI)
Binding site454(R)-2-hydroxyglutarate (UniProtKB | ChEBI)
Binding site486Zn2+ (UniProtKB | ChEBI)
Binding site487(R)-2-hydroxyglutarate (UniProtKB | ChEBI)
Binding site487(R)-lactate (UniProtKB | ChEBI)
Binding site487(R)-malate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrion
Molecular Function(R)-2-hydroxyglutarate dehydrogenase activity
Molecular FunctionFAD binding
Molecular Functionzinc ion binding
Biological Processmalate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    D-2-hydroxyglutarate dehydrogenase, mitochondrial
  • EC number

Gene names

    • Name
      d2hgdh
    • ORF names
      zgc:158661

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    A1L258

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for transit peptide, chain.

TypeIDPosition(s)Description
Transit peptide1-55Mitochondrion
ChainPRO_000034723556-533D-2-hydroxyglutarate dehydrogenase, mitochondrial

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain107-286FAD-binding PCMH-type

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    533
  • Mass (Da)
    58,714
  • Last updated
    2007-02-06 v1
  • Checksum
    A6636E8DB7B1485A
MGLFQKCSRLSLRSSYMWSVCPQYSIAVTARETPDRALIVHWTQHRDVHNSRRLGANPANPSAAPPRLPFSRVTQEDLSFFRALLPGRTITDPDLLKSSNVDWLKTVQGSSDVLLRPKTTEGVSQILRYCNERNLAVCPQGGNTGLVGGSVPVFDEIILSTSLMNQVFAFDNISGILTCQAGCVLENLSHYLEERDFIMPLDLGAKGSCHIGGNVSTNAGGLRLLRYGSLRGTVLGLEVVLADGHVLNCLATLRKDNTGYDLKQLFIGSEGTLGVITAVSILCPRKPKAVNVAFLGCSSFQQLLETFQCCRGMLGEILSAFEFLDASCMNLLEKHLKLTNPITECPFYIVIETAGSNATHDEEKLHQFLEEVMTSSLVTDGTVATEATKIKALWSLRERVTEALTHEGYTYKYDISLPVEKIYDLVQDMRRHLGGMAKNVVGYGHVGDGNLHLNITSPSKDFDLLAAIEPYVYEWTSQWKGSISAEHGLGLKKRNYIYYSKPSEAVALMGSIKAMLDPKGILNPYKTLPDNIN

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
F1R1R3F1R1R3_DANREd2hgdh533

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC129361
EMBL· GenBank· DDBJ
AAI29362.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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