A1L244 · SAC1B_DANRE
- ProteinPhosphatidylinositol-3-phosphatase SAC1-B
- Genesacm1lb
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids586 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns4P), phosphatidylinositol 3-phosphate (PtdIns3P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2).
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphateThis reaction proceeds in the forward direction.
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphateThis reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | endoplasmic reticulum-plasma membrane contact site | |
Cellular Component | Golgi membrane | |
Molecular Function | phosphatase activity | |
Molecular Function | phosphatidylinositol-3-phosphate phosphatase activity | |
Molecular Function | phosphatidylinositol-4-phosphate phosphatase activity | |
Biological Process | phosphatidylinositol dephosphorylation |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphatidylinositol-3-phosphatase SAC1-B
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA1L244
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Golgi apparatus membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-519 | Cytoplasmic | ||||
Sequence: MASTYNSFNLHTTAEKFYIEACDDGVGDVLAIDRVSTEKTLTVRKDVPPSAVTRPICGIMGTIRLVAGVYLIVITKKKKVGDLLGHAVWKASDFDIISYKKTVLHLTDNQMQDNKVFLSMLNSVLNTDGFYFATDYDLTHTLQRLSNTSPEFQEMTLLERADQRFVWNGHLLREFMAQPELHRFVFPVIHGFIAMRSCCINGKIFDWNLISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIIQYNGAKASFIQTRGSIPFYWSQRPNLKYKPKPQISKSINHLDGFQRHFDSQIIIYGKQVILNLVNQKGSEKPLEQAFAKMVGSLGNGMIKYIAFDFHKECSRMRWHRLQILVDTVAELQDEFGYFLVDSDGSVQMQQDGTFRSNCMDCLDRTNVVQSLLARRSLQSQLERMAVLHVGQRIEEQADFEKIYKNAWADNANACAKQYAGTGALKTDFTRTGKRTQWGLLMDGWNSMIRYYKNNFSDGFRQDSIDLFLGNYAVEEADMNTPLHEPKDWK | ||||||
Transmembrane | 520-540 | Helical | ||||
Sequence: FLTLPIIMVVAFSMCIICLLM | ||||||
Topological domain | 541-547 | Lumenal | ||||
Sequence: AGDTWTE | ||||||
Transmembrane | 548-568 | Helical | ||||
Sequence: TLAYVLFWGSASVVTGGVILF | ||||||
Topological domain | 569-586 | Cytoplasmic | ||||
Sequence: NGRDFVDAPRLVQKEKMD |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000317175 | 1-586 | Phosphatidylinositol-3-phosphatase SAC1-B | |||
Sequence: MASTYNSFNLHTTAEKFYIEACDDGVGDVLAIDRVSTEKTLTVRKDVPPSAVTRPICGIMGTIRLVAGVYLIVITKKKKVGDLLGHAVWKASDFDIISYKKTVLHLTDNQMQDNKVFLSMLNSVLNTDGFYFATDYDLTHTLQRLSNTSPEFQEMTLLERADQRFVWNGHLLREFMAQPELHRFVFPVIHGFIAMRSCCINGKIFDWNLISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIIQYNGAKASFIQTRGSIPFYWSQRPNLKYKPKPQISKSINHLDGFQRHFDSQIIIYGKQVILNLVNQKGSEKPLEQAFAKMVGSLGNGMIKYIAFDFHKECSRMRWHRLQILVDTVAELQDEFGYFLVDSDGSVQMQQDGTFRSNCMDCLDRTNVVQSLLARRSLQSQLERMAVLHVGQRIEEQADFEKIYKNAWADNANACAKQYAGTGALKTDFTRTGKRTQWGLLMDGWNSMIRYYKNNFSDGFRQDSIDLFLGNYAVEEADMNTPLHEPKDWKFLTLPIIMVVAFSMCIICLLMAGDTWTETLAYVLFWGSASVVTGGVILFNGRDFVDAPRLVQKEKMD |
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 121-450 | SAC | ||||
Sequence: LNSVLNTDGFYFATDYDLTHTLQRLSNTSPEFQEMTLLERADQRFVWNGHLLREFMAQPELHRFVFPVIHGFIAMRSCCINGKIFDWNLISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIIQYNGAKASFIQTRGSIPFYWSQRPNLKYKPKPQISKSINHLDGFQRHFDSQIIIYGKQVILNLVNQKGSEKPLEQAFAKMVGSLGNGMIKYIAFDFHKECSRMRWHRLQILVDTVAELQDEFGYFLVDSDGSVQMQQDGTFRSNCMDCLDRTNVVQSLLARRSLQSQLERMAVLHVGQRIEEQADFEKIYKNAWADNANACAKQYAG | ||||||
Region | 451-586 | Essential for phosphatidylinositol-4-phosphate phosphatase activity | ||||
Sequence: TGALKTDFTRTGKRTQWGLLMDGWNSMIRYYKNNFSDGFRQDSIDLFLGNYAVEEADMNTPLHEPKDWKFLTLPIIMVVAFSMCIICLLMAGDTWTETLAYVLFWGSASVVTGGVILFNGRDFVDAPRLVQKEKMD |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length586
- Mass (Da)66,932
- Last updated2007-02-06 v1
- Checksum501148B8A763F25D
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC129344 EMBL· GenBank· DDBJ | AAI29345.1 EMBL· GenBank· DDBJ | mRNA |