A1IG88 · A1IG88_ALIFS
- ProteinHypoxanthine phosphoribosyltransferase
- Genehpt
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids176 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Purine salvage pathway enzyme which catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of hypoxanthine to yield IMP (inosine 5'-monophosphate). To a lesser extent, can also act on guanine leading to GMP, but shows a highly less efficient activity with xanthine.
Catalytic activity
- GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphateThis reaction proceeds in the backward direction.
Cofactor
Pathway
Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | guanine phosphoribosyltransferase activity | |
Molecular Function | hypoxanthine phosphoribosyltransferase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | nucleotide binding | |
Biological Process | GMP salvage | |
Biological Process | guanine salvage | |
Biological Process | hypoxanthine metabolic process | |
Biological Process | IMP salvage | |
Biological Process | purine ribonucleoside salvage |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHypoxanthine phosphoribosyltransferase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Vibrionales > Vibrionaceae > Aliivibrio
Accessions
- Primary accessionA1IG88
Subcellular Location
Structure
Sequence
- Sequence statusComplete
- Length176
- Mass (Da)19,832
- Last updated2007-02-06 v1
- Checksum8E14133C863FF8EB
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB086190 EMBL· GenBank· DDBJ | BAF43662.1 EMBL· GenBank· DDBJ | Genomic DNA |