A1IG88 · A1IG88_ALIFS

Function

function

Purine salvage pathway enzyme which catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of hypoxanthine to yield IMP (inosine 5'-monophosphate). To a lesser extent, can also act on guanine leading to GMP, but shows a highly less efficient activity with xanthine.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionguanine phosphoribosyltransferase activity
Molecular Functionhypoxanthine phosphoribosyltransferase activity
Molecular Functionmagnesium ion binding
Molecular Functionnucleotide binding
Biological ProcessGMP salvage
Biological Processguanine salvage
Biological Processhypoxanthine metabolic process
Biological ProcessIMP salvage
Biological Processpurine ribonucleoside salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Hypoxanthine phosphoribosyltransferase
  • EC number

Gene names

    • Name
      hpt

Organism names

Accessions

  • Primary accession
    A1IG88

Subcellular Location

Keywords

Family & Domains

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    176
  • Mass (Da)
    19,832
  • Last updated
    2007-02-06 v1
  • Checksum
    8E14133C863FF8EB
MKHTVEVMISEQEVNQRVKELGQQISEHYKDSEGLVMVGLLRGSFVFMADLARAIDVPMTVDFMTASSYGNNMESTRDVRILKDLDDDIKGKDVLLVEDIIDTGNTLSKVCEILSIREPNSITICTLLDKPSRREVEVNVDWIGFSIPDEFVVGVGIDYAQKYRNLSYIGKVVPQE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB086190
EMBL· GenBank· DDBJ
BAF43662.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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