A1HM42 · A1HM42_9FIRM

Function

function

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.

Activity regulation

Allosterically activated by GTP.

Pathway

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site785-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site1035-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site130-1385-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site193uracil (UniProtKB | ChEBI)
Binding site198-200uracil (UniProtKB | ChEBI)
Binding site1995-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Molecular Functionuracil phosphoribosyltransferase activity
Biological ProcessUMP salvage
Biological Processuracil salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uracil phosphoribosyltransferase
  • EC number
  • Alternative names
    • UMP pyrophosphorylase
    • UPRTase

Gene names

    • Name
      upp
    • ORF names
      TcarDRAFT_2582

Organism names

Accessions

  • Primary accession
    A1HM42

Proteomes

Family & Domains

Sequence similarities

Belongs to the UPRTase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    208
  • Mass (Da)
    22,933
  • Last updated
    2007-02-06 v1
  • Checksum
    EA0FDB313515B015
MKVQIIEHPLVQHKLTLLRDKNTGTKEFRELLDEIALLMGYELTRNLPLQDVEIETPVAKCFCKMLTGKKIGFIPVLRAGLGMVNGLLKLIPAAKVGHIGLYRDPDTLTPIEYYCKLPSDTAERELIIVDPMLATGESLVAAIDLLKRHGAKDIKLICLVAAPEGVLLINQKHPDVKIFTAAVDDYLNDHGYIVPGLGDAGDRIFGTK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAWL01000001
EMBL· GenBank· DDBJ
EAX48893.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp