A1DSF3 · A1DSF3_HUMAN
- ProteinCytochrome c oxidase subunit 1
- GeneCOX1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids513 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)This reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Cofactor
Protein has several cofactor binding sites:
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | oxidative phosphorylation |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA1DSF3
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 18-37 | Helical | ||||
Sequence: LYLLFGAWAGVLGTALSLLI | ||||||
Transmembrane | 57-83 | Helical | ||||
Sequence: IVTAHAFVMIFFMVMPIMIGGFGNWLV | ||||||
Transmembrane | 104-128 | Helical | ||||
Sequence: LLPPSLLLLLASAMVEAGAGTGWTV | ||||||
Transmembrane | 148-171 | Helical | ||||
Sequence: FSLHLAGVSSILGAINFITTIINM | ||||||
Transmembrane | 183-210 | Helical | ||||
Sequence: LFVWSILITAVLLLLSLPVLAAGITMLL | ||||||
Transmembrane | 243-261 | Helical | ||||
Sequence: VYILILPGFGMISHIVTYY | ||||||
Transmembrane | 268-291 | Helical | ||||
Sequence: FGYMGMVWAMMSIGFLGFIVWAHH | ||||||
Transmembrane | 303-325 | Helical | ||||
Sequence: AYFTSATMIIAIPTGVKVFSWLA | ||||||
Transmembrane | 337-359 | Helical | ||||
Sequence: AVLWALGFIFLFTVGGLTGIVLA | ||||||
Transmembrane | 379-400 | Helical | ||||
Sequence: YVLSMGAVFAIMGGFIHWFPLF | ||||||
Transmembrane | 412-430 | Helical | ||||
Sequence: IHFTIMFIGVNLTFFPQHF | ||||||
Transmembrane | 450-473 | Helical | ||||
Sequence: WNILSSVGSFISLTAVMLMIFMIW |
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-511 | Cytochrome oxidase subunit I profile | ||||
Sequence: MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSILITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEPVYM |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length513
- Mass (Da)57,055
- Last updated2007-01-23 v1
- Checksum72918270589549F1
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EF060319 EMBL· GenBank· DDBJ | ABJ89046.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF153789 EMBL· GenBank· DDBJ | ABL60244.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF153820 EMBL· GenBank· DDBJ | ABL60647.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM346923 EMBL· GenBank· DDBJ | ADI80136.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ703243 EMBL· GenBank· DDBJ | AFF80119.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ704528 EMBL· GenBank· DDBJ | AFF96824.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX153807 EMBL· GenBank· DDBJ | AFO33666.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX153808 EMBL· GenBank· DDBJ | AFO33679.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX153812 EMBL· GenBank· DDBJ | AFO33731.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX900545 EMBL· GenBank· DDBJ | AGC18101.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX900555 EMBL· GenBank· DDBJ | AGC18231.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF450955 EMBL· GenBank· DDBJ | AGZ66050.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ446723 EMBL· GenBank· DDBJ | AHX55455.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP240740 EMBL· GenBank· DDBJ | ALD85937.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU682933 EMBL· GenBank· DDBJ | AOR42062.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU683032 EMBL· GenBank· DDBJ | AOR43349.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU683111 EMBL· GenBank· DDBJ | AOR44376.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU683338 EMBL· GenBank· DDBJ | AOR47327.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU683373 EMBL· GenBank· DDBJ | AOR47782.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU683410 EMBL· GenBank· DDBJ | AOR48263.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU683422 EMBL· GenBank· DDBJ | AOR48419.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU683475 EMBL· GenBank· DDBJ | AOR49108.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU683590 EMBL· GenBank· DDBJ | AOR50603.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX457171 EMBL· GenBank· DDBJ | APD62254.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX457296 EMBL· GenBank· DDBJ | APD63879.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY399150 EMBL· GenBank· DDBJ | AQU13169.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY408302 EMBL· GenBank· DDBJ | AQU17338.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY408448 EMBL· GenBank· DDBJ | AQU19236.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY408557 EMBL· GenBank· DDBJ | AQU20653.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY408680 EMBL· GenBank· DDBJ | AQU22252.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY409220 EMBL· GenBank· DDBJ | AQU29272.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY409271 EMBL· GenBank· DDBJ | AQU29935.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY409695 EMBL· GenBank· DDBJ | AQU35447.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY409751 EMBL· GenBank· DDBJ | AQU36175.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY410053 EMBL· GenBank· DDBJ | AQU40101.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY410165 EMBL· GenBank· DDBJ | AQU41557.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF057768 EMBL· GenBank· DDBJ | ASS20071.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF057774 EMBL· GenBank· DDBJ | ASS20149.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF058406 EMBL· GenBank· DDBJ | ASS28352.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY681007 EMBL· GenBank· DDBJ | ASZ83182.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG571199 EMBL· GenBank· DDBJ | AUG60659.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH351262 EMBL· GenBank· DDBJ | AWK97755.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK860658 EMBL· GenBank· DDBJ | QEG54546.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT419244 EMBL· GenBank· DDBJ | QMP94695.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT419263 EMBL· GenBank· DDBJ | QMP94942.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN857256 EMBL· GenBank· DDBJ | QTK13885.1 EMBL· GenBank· DDBJ | Genomic DNA |