A1DSF3 · A1DSF3_HUMAN

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COX1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processoxidative phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COX1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 7_M1a1b1
    • Buryat_423
    • Khamnigan_83
    • PUT202
    • PUT231
    • CHP060_Chachapoya
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A1DSF3

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane18-37Helical
Transmembrane57-83Helical
Transmembrane104-128Helical
Transmembrane148-171Helical
Transmembrane183-210Helical
Transmembrane243-261Helical
Transmembrane268-291Helical
Transmembrane303-325Helical
Transmembrane337-359Helical
Transmembrane379-400Helical
Transmembrane412-430Helical
Transmembrane450-473Helical

Keywords

PTM/Processing

Proteomic databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-511Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    513
  • Mass (Da)
    57,055
  • Last updated
    2007-01-23 v1
  • Checksum
    72918270589549F1
MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSILITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEPVYMKS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EF060319
EMBL· GenBank· DDBJ
ABJ89046.1
EMBL· GenBank· DDBJ
Genomic DNA
EF153789
EMBL· GenBank· DDBJ
ABL60244.1
EMBL· GenBank· DDBJ
Genomic DNA
EF153820
EMBL· GenBank· DDBJ
ABL60647.1
EMBL· GenBank· DDBJ
Genomic DNA
HM346923
EMBL· GenBank· DDBJ
ADI80136.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ703243
EMBL· GenBank· DDBJ
AFF80119.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ704528
EMBL· GenBank· DDBJ
AFF96824.1
EMBL· GenBank· DDBJ
Genomic DNA
JX153807
EMBL· GenBank· DDBJ
AFO33666.1
EMBL· GenBank· DDBJ
Genomic DNA
JX153808
EMBL· GenBank· DDBJ
AFO33679.1
EMBL· GenBank· DDBJ
Genomic DNA
JX153812
EMBL· GenBank· DDBJ
AFO33731.1
EMBL· GenBank· DDBJ
Genomic DNA
JX900545
EMBL· GenBank· DDBJ
AGC18101.1
EMBL· GenBank· DDBJ
Genomic DNA
JX900555
EMBL· GenBank· DDBJ
AGC18231.1
EMBL· GenBank· DDBJ
Genomic DNA
KF450955
EMBL· GenBank· DDBJ
AGZ66050.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ446723
EMBL· GenBank· DDBJ
AHX55455.1
EMBL· GenBank· DDBJ
Genomic DNA
KP240740
EMBL· GenBank· DDBJ
ALD85937.1
EMBL· GenBank· DDBJ
Genomic DNA
KU682933
EMBL· GenBank· DDBJ
AOR42062.1
EMBL· GenBank· DDBJ
Genomic DNA
KU683032
EMBL· GenBank· DDBJ
AOR43349.1
EMBL· GenBank· DDBJ
Genomic DNA
KU683111
EMBL· GenBank· DDBJ
AOR44376.1
EMBL· GenBank· DDBJ
Genomic DNA
KU683338
EMBL· GenBank· DDBJ
AOR47327.1
EMBL· GenBank· DDBJ
Genomic DNA
KU683373
EMBL· GenBank· DDBJ
AOR47782.1
EMBL· GenBank· DDBJ
Genomic DNA
KU683410
EMBL· GenBank· DDBJ
AOR48263.1
EMBL· GenBank· DDBJ
Genomic DNA
KU683422
EMBL· GenBank· DDBJ
AOR48419.1
EMBL· GenBank· DDBJ
Genomic DNA
KU683475
EMBL· GenBank· DDBJ
AOR49108.1
EMBL· GenBank· DDBJ
Genomic DNA
KU683590
EMBL· GenBank· DDBJ
AOR50603.1
EMBL· GenBank· DDBJ
Genomic DNA
KX457171
EMBL· GenBank· DDBJ
APD62254.1
EMBL· GenBank· DDBJ
Genomic DNA
KX457296
EMBL· GenBank· DDBJ
APD63879.1
EMBL· GenBank· DDBJ
Genomic DNA
KY399150
EMBL· GenBank· DDBJ
AQU13169.1
EMBL· GenBank· DDBJ
Genomic DNA
KY408302
EMBL· GenBank· DDBJ
AQU17338.1
EMBL· GenBank· DDBJ
Genomic DNA
KY408448
EMBL· GenBank· DDBJ
AQU19236.1
EMBL· GenBank· DDBJ
Genomic DNA
KY408557
EMBL· GenBank· DDBJ
AQU20653.1
EMBL· GenBank· DDBJ
Genomic DNA
KY408680
EMBL· GenBank· DDBJ
AQU22252.1
EMBL· GenBank· DDBJ
Genomic DNA
KY409220
EMBL· GenBank· DDBJ
AQU29272.1
EMBL· GenBank· DDBJ
Genomic DNA
KY409271
EMBL· GenBank· DDBJ
AQU29935.1
EMBL· GenBank· DDBJ
Genomic DNA
KY409695
EMBL· GenBank· DDBJ
AQU35447.1
EMBL· GenBank· DDBJ
Genomic DNA
KY409751
EMBL· GenBank· DDBJ
AQU36175.1
EMBL· GenBank· DDBJ
Genomic DNA
KY410053
EMBL· GenBank· DDBJ
AQU40101.1
EMBL· GenBank· DDBJ
Genomic DNA
KY410165
EMBL· GenBank· DDBJ
AQU41557.1
EMBL· GenBank· DDBJ
Genomic DNA
MF057768
EMBL· GenBank· DDBJ
ASS20071.1
EMBL· GenBank· DDBJ
Genomic DNA
MF057774
EMBL· GenBank· DDBJ
ASS20149.1
EMBL· GenBank· DDBJ
Genomic DNA
MF058406
EMBL· GenBank· DDBJ
ASS28352.1
EMBL· GenBank· DDBJ
Genomic DNA
KY681007
EMBL· GenBank· DDBJ
ASZ83182.1
EMBL· GenBank· DDBJ
Genomic DNA
MG571199
EMBL· GenBank· DDBJ
AUG60659.1
EMBL· GenBank· DDBJ
Genomic DNA
MH351262
EMBL· GenBank· DDBJ
AWK97755.1
EMBL· GenBank· DDBJ
Genomic DNA
MK860658
EMBL· GenBank· DDBJ
QEG54546.1
EMBL· GenBank· DDBJ
Genomic DNA
MT419244
EMBL· GenBank· DDBJ
QMP94695.1
EMBL· GenBank· DDBJ
Genomic DNA
MT419263
EMBL· GenBank· DDBJ
QMP94942.1
EMBL· GenBank· DDBJ
Genomic DNA
MN857256
EMBL· GenBank· DDBJ
QTK13885.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp