A1DA65 · FTMG_NEOFI

Function

function

Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of fumitremorgins, indole alkaloids that carry not only intriguing chemical structures, but also interesting biological and pharmacological activities (PubMed:23109474).
The biosynthesis of fumitremorgin-type alkaloids begins by condensation of the two amino acids L-tryptophan and L-proline to brevianamide F, catalyzed by the non-ribosomal peptide synthetase ftmPS/ftmA (By similarity).
Brevianamide F is then prenylated by the prenyltransferase ftmPT1/ftmB in the presence of dimethylallyl diphosphate, resulting in the formation of tryprostatin B (By similarity).
The three cytochrome P450 monooxygenases, ftmP450-1/ftmC, ftmP450-2/ftmE and ftmP450-3/FtmG, are responsible for the conversion of tryprostatin B to 6-hydroxytryprostatin B, tryprostatin A to fumitremorgin C and fumitremorgin C to 12,13-dihydroxyfumitremorgin C, respectively (By similarity).
The putative methyltransferase ftmMT/ftmD is expected for the conversion of 6-hydroxytryprostatin B to tryprostatin A (By similarity).
FtmPT2/FtmH catalyzes the prenylation of 12,13-dihydroxyfumitre-morgin C in the presence of dimethylallyl diphosphate, resulting in the formation of fumitremorgin B (By similarity).
Fumitremorgin B is further converted to verruculogen by ftmOx1/ftmF via the insertion of an endoperoxide bond between the two prenyl moieties (By similarity).
Finally, verruculogen is further converted to fumitremorgin A by the verruculogen prenyltransferase ftmPT3 (PubMed:23109474).

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Mycotoxin biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site442Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functionheme binding
Molecular Functioniron ion binding
Molecular Functionmonooxygenase activity
Molecular Functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Biological Processalkaloid metabolic process
Biological Processbiosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fumitremorgin C monooxygenase
  • EC number
  • Alternative names
    • Fumitremorgin biosynthesis protein G

Gene names

    • Name
      ftmP450-3
    • Synonyms
      ftmG
    • ORF names
      NFIA_093750

Organism names

Accessions

  • Primary accession
    A1DA65

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane9-29Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004241261-504Fumitremorgin C monooxygenase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the cytochrome P450 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    504
  • Mass (Da)
    57,231
  • Last updated
    2007-01-23 v1
  • Checksum
    8797F1A7339B8999
METFDAIQLPYPGVVGASLLVILGIILLFPLDTGHFISINQHPWDFFQTKAKQEFEYNAAALLNEGLQTGRSAFRLVTNMVTYLILKDQYAEEIKNDSRFGAHEAVDPVLLVDLPGLETMFQGSLHNQVPPMAVRALNKELVHLTPFLSEEAMNCLQTRWTDSAEWHDVSIPETVLALIAQMTTRALLGPALCRNPEWLDIAKSFTTNRAIAVAAVQSWPSFLQPVIHWFLSPCRALRRQIQCARNILLPVLERERRSYRSDQPTKREFSNLAFIDQYAKGARYDATMAQLRIIAVAFQTTSDLVEKVIARLCKHPELIQPLREEVVSVVGKNGLHSHSLRKLTLMESVMKETQRLEPAVIIGMFRLAKEKVTLKDGTVIPKGTNIAFANDLRFDPEMYPEPETFDGYRFQRMREDPEKIDLTPFTKTRMSHLAFGHGKHACPGRFLACDEAKLILCHILLKYEIRAVEGSPPELRARGMFVQLDPGAMMSVRRRRENEFALHG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS027694
EMBL· GenBank· DDBJ
EAW19755.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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