A1DA64 · FTMF_NEOFI

Function

function

Verruculogen synthase; part of the gene cluster that mediates the biosynthesis of fumitremorgins, indole alkaloids that carry not only intriguing chemical structures, but also interesting biological and pharmacological activities (PubMed:23109474).
The biosynthesis of fumitremorgin-type alkaloids begins by condensation of the two amino acids L-tryptophan and L-proline to brevianamide F, catalyzed by the non-ribosomal peptide synthetase ftmPS/ftmA (By similarity).
Brevianamide F is then prenylated by the prenyltransferase ftmPT1/ftmB in the presence of dimethylallyl diphosphate, resulting in the formation of tryprostatin B (By similarity).
The three cytochrome P450 monooxygenases, ftmP450-1/ftmC, ftmP450-2/ftmE and ftmP450-3/FtmG, are responsible for the conversion of tryprostatin B to 6-hydroxytryprostatin B, tryprostatin A to fumitremorgin C and fumitremorgin C to 12,13-dihydroxyfumitremorgin C, respectively (By similarity).
The putative methyltransferase ftmMT/ftmD is expected for the conversion of 6-hydroxytryprostatin B to tryprostatin A (By similarity).
FtmPT2/FtmH catalyzes the prenylation of 12,13-dihydroxyfumitre-morgin C in the presence of dimethylallyl diphosphate, resulting in the formation of fumitremorgin B (By similarity).
Fumitremorgin B is further converted to verruculogen by ftmOx1/ftmF via the insertion of an endoperoxide bond between the two prenyl moieties (By similarity).
Finally, verruculogen is further converted to fumitremorgin A by the verruculogen prenyltransferase ftmPT3 (PubMed:23109474).

Catalytic activity

Cofactor

Fe cation (UniProtKB | Rhea| CHEBI:24875 )

Pathway

Mycotoxin biosynthesis.

GO annotations

AspectTerm
Molecular Functiondioxygenase activity
Biological Processalkaloid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Verruculogen synthase
  • EC number
  • Alternative names
    • Fumitremorgin biosynthesis protein F

Gene names

    • Name
      ftmOx1
    • Synonyms
      ftmF
    • ORF names
      NFIA_093740

Organism names

Accessions

  • Primary accession
    A1DA64

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004241351-291Verruculogen synthase

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the PhyH family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    291
  • Mass (Da)
    32,740
  • Last updated
    2007-01-23 v1
  • Checksum
    BCCA28B1BA1AFE72
MTVDSKPQLQRLAADVDVDLMCRLLEEDGAFILKDLLPLDVVESFNRELDVQMAIPPPKGERLLADKYPPHFKYVPNVATTCPTFRNNILINPVIHAICEGYFQRTGDYWLSAAFLREIESGMPAQPFHRDDATHPLMHHQPLEAPPISLSVIFPLTEFTEENGATEVILGSHRWMEVGTPERDQAVLATMDPGDVLVVRQRVVHAGGGNRTTTGDPRRVVLAYFNSCQLTPFETYRTMPRETVESMTVLGQRMLGWRTMKPSDPNIVGINIIDDKRLENVLQLKATDLPA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS027694
EMBL· GenBank· DDBJ
EAW19754.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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