A1D9C9 · XYL2_NEOFI
- ProteinProbable D-xylulose reductase A
- GenexdhA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids358 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway (By similarity).
Catalytic activity
- xylitol + NAD+ = D-xylulose + NADH + H+
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 47 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 72 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 73 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 182-187 | NAD+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | D-xylulose reductase activity | |
Molecular Function | L-iditol 2-dehydrogenase (NAD+) activity | |
Molecular Function | zinc ion binding | |
Biological Process | D-xylose metabolic process | |
Biological Process | L-arabinose catabolic process to xylulose 5-phosphate | |
Biological Process | sorbitol catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable D-xylulose reductase A
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Fumigati
Accessions
- Primary accessionA1D9C9
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000393515 | 1-358 | Probable D-xylulose reductase A | ||
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length358
- Mass (Da)38,085
- Last updated2007-01-23 v1
- ChecksumAA0A6C0EBE049730
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DS027692 EMBL· GenBank· DDBJ | EAW20990.1 EMBL· GenBank· DDBJ | Genomic DNA |