A1D291 · A1D291_NEOFI

Function

function

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site108Zn2+ (UniProtKB | ChEBI)
Binding site110Zn2+ (UniProtKB | ChEBI)
Binding site135Zn2+ (UniProtKB | ChEBI)
Binding site292Zn2+ (UniProtKB | ChEBI)
Active site311

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmannose-6-phosphate isomerase activity
Molecular Functionzinc ion binding
Biological Processcarbohydrate metabolic process
Biological Processcell wall mannoprotein biosynthetic process
Biological ProcessGDP-mannose biosynthetic process
Biological Processprotein glycosylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Mannose-6-phosphate isomerase
  • EC number

Gene names

    • ORF names
      NFIA_012230

Organism names

Accessions

  • Primary accession
    A1D291

Proteomes

Organism-specific databases

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-152Phosphomannose isomerase type I catalytic
Domain168-273Phosphomannose isomerase type I helical insertion
Domain362-408Phosphomannose isomerase type I C-terminal

Sequence similarities

Belongs to the mannose-6-phosphate isomerase type 1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    457
  • Mass (Da)
    49,923
  • Last updated
    2007-01-23 v1
  • Checksum
    9DC7CFBF97F0850A
MPPVPLLRLQCGVNSYDWGKVGHESAAAKYAATTAASDFSIQSDKPYAELWMGTHPSLPSKDLETQRTLLDMVQDNQALISQEVSERYGGKLPFLFKVLSIRKALSIQAHPNKKLAEKLHARDPRNYPDDNHKPEMTIAITPFEGLCGFRPLVEITHFLKAVAPLRQLVGERAASEFENTVKGSEESEDPAVTEKNKQALRTLFTSLMRSSPESIEAATKELVAMAQNSSETFATSSSTPETNPTNPAELAAITVRLNGQFPNDIGSFVFFFLNFVKLEPGEAMFLKADDIHAYISGDIIECMASSDNVVRAGFTPKFKDVDTLVDMLTYSYAPIAEQKLEPTDYPYAVLNAPAYSSGSSCILYDPPIEEFSVIKTDLKRQGAKATFDGISGPSIVICTAGAGKITVGPKTQEVKEGYVFFVGANAECIIESTGEDTFTTFKAFCDLTGKEDMVNGN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS027688
EMBL· GenBank· DDBJ
EAW22534.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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