A1D291 · A1D291_NEOFI
- ProteinMannose-6-phosphate isomerase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids457 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Catalytic activity
- D-mannose 6-phosphate = D-fructose 6-phosphate
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 108 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 110 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 135 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 292 | Zn2+ (UniProtKB | ChEBI) | |||
Active site | 311 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | mannose-6-phosphate isomerase activity | |
Molecular Function | zinc ion binding | |
Biological Process | carbohydrate metabolic process | |
Biological Process | cell wall mannoprotein biosynthetic process | |
Biological Process | GDP-mannose biosynthetic process | |
Biological Process | protein glycosylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMannose-6-phosphate isomerase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Fumigati
Accessions
- Primary accessionA1D291
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 6-152 | Phosphomannose isomerase type I catalytic | |||
Domain | 168-273 | Phosphomannose isomerase type I helical insertion | |||
Domain | 362-408 | Phosphomannose isomerase type I C-terminal | |||
Sequence similarities
Belongs to the mannose-6-phosphate isomerase type 1 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length457
- Mass (Da)49,923
- Last updated2007-01-23 v1
- Checksum9DC7CFBF97F0850A
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DS027688 EMBL· GenBank· DDBJ | EAW22534.1 EMBL· GenBank· DDBJ | Genomic DNA |