A1CBB8 · ATG18_ASPCL

Function

function

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct atg9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentendosome membrane
Cellular Componentextrinsic component of membrane
Cellular Componentfungal-type vacuole membrane
Cellular Componentphagophore assembly site membrane
Molecular Functionphosphatidylinositol-3,5-bisphosphate binding
Molecular Functionphosphatidylinositol-3-phosphate binding
Biological Processautophagy of mitochondrion
Biological Processnucleophagy
Biological Processprotein localization to phagophore assembly site
Biological Processprotein transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Autophagy-related protein 18

Gene names

    • Name
      atg18
    • ORF names
      ACLA_014730

Organism names

Accessions

  • Primary accession
    A1CBB8

Proteomes

Organism-specific databases

Subcellular Location

Preautophagosomal structure membrane
; Peripheral membrane protein
Vacuole membrane
; Peripheral membrane protein
Endosome membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003179951-417

Interaction

Subunit

Component of the PI(3,5)P2 regulatory complex.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for repeat, motif, compositional bias, region.

TypeIDPosition(s)Description
Repeat1-36WD 1
Repeat69-114WD 2
Repeat139-182WD 3
Repeat185-225WD 4
Motif226-230L/FRRG motif
Repeat230-269WD 5
Compositional bias261-295Polar residues
Region261-314Disordered
Repeat312-358WD 6
Repeat370-410WD 7

Domain

The N-terminus might form a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane.
The L/FRRG motif is essential for the cytoplasm to vacuole transport (Cvt) pathway, for the recruitment of atg8 and atg16 to the PAS in nutrient-rich medium, and for its recruitment to and dissociation from the PAS under starvation conditions.

Sequence similarities

Belongs to the WD repeat PROPPIN family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    417
  • Mass (Da)
    45,374
  • Last updated
    2007-01-23 v1
  • Checksum
    B5B5B357E80423F2
MAMNFVTFNQDYSYLAVATSKGFRIFTTDPFAKSYETKEGHIAIIEMLFSTSLVALILSPRRLQITNTKRQSTICELTFPTTVLAVKLNRKRLVIVLEDQIYLYDIQTMKLLYTIQTSPNPNAICALSPSSDNCYLAYPLPQKAPPSSFTPPSHAPPGNTHVSPTSGEVLIFDSLKLEAINVIEAHRSPLACITLNSDGTLLATASDKGTIIRVFSVPDGHKLYQFRRGSMPSRIFSMSFNTTSTLLCVSSSTETIHLFKLSQQTSSSRDTSPSSSTPAGRDRAFSQSSLGHSPDRSDVSGEPDSSEFPARKHNGTLMGIIRRTSQNVGSTVAAKVGGYLPKGVSEMWEPARDFAWIKLPKPSQNAGGSGNNGPLRSVVAMSNNTPQVMVITSDGNFYVFSIDLSKGGEGTLTKQYS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias261-295Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS027049
EMBL· GenBank· DDBJ
EAW13036.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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