A1CBB8 · ATG18_ASPCL
- ProteinAutophagy-related protein 18
- Geneatg18
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids417 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct atg9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | endosome membrane | |
Cellular Component | extrinsic component of membrane | |
Cellular Component | fungal-type vacuole membrane | |
Cellular Component | phagophore assembly site membrane | |
Molecular Function | phosphatidylinositol-3,5-bisphosphate binding | |
Molecular Function | phosphatidylinositol-3-phosphate binding | |
Biological Process | autophagy of mitochondrion | |
Biological Process | nucleophagy | |
Biological Process | protein localization to phagophore assembly site | |
Biological Process | protein transport |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameAutophagy-related protein 18
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Fumigati
Accessions
- Primary accessionA1CBB8
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Preautophagosomal structure membrane ; Peripheral membrane protein
Vacuole membrane ; Peripheral membrane protein
Endosome membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000317995 | 1-417 | Autophagy-related protein 18 | |||
Sequence: MAMNFVTFNQDYSYLAVATSKGFRIFTTDPFAKSYETKEGHIAIIEMLFSTSLVALILSPRRLQITNTKRQSTICELTFPTTVLAVKLNRKRLVIVLEDQIYLYDIQTMKLLYTIQTSPNPNAICALSPSSDNCYLAYPLPQKAPPSSFTPPSHAPPGNTHVSPTSGEVLIFDSLKLEAINVIEAHRSPLACITLNSDGTLLATASDKGTIIRVFSVPDGHKLYQFRRGSMPSRIFSMSFNTTSTLLCVSSSTETIHLFKLSQQTSSSRDTSPSSSTPAGRDRAFSQSSLGHSPDRSDVSGEPDSSEFPARKHNGTLMGIIRRTSQNVGSTVAAKVGGYLPKGVSEMWEPARDFAWIKLPKPSQNAGGSGNNGPLRSVVAMSNNTPQVMVITSDGNFYVFSIDLSKGGEGTLTKQYS |
Interaction
Structure
Family & Domains
Features
Showing features for repeat, motif, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 1-36 | WD 1 | ||||
Sequence: MAMNFVTFNQDYSYLAVATSKGFRIFTTDPFAKSYE | ||||||
Repeat | 69-114 | WD 2 | ||||
Sequence: KRQSTICELTFPTTVLAVKLNRKRLVIVLEDQIYLYDIQTMKLLYT | ||||||
Repeat | 139-182 | WD 3 | ||||
Sequence: PLPQKAPPSSFTPPSHAPPGNTHVSPTSGEVLIFDSLKLEAINV | ||||||
Repeat | 185-225 | WD 4 | ||||
Sequence: AHRSPLACITLNSDGTLLATASDKGTIIRVFSVPDGHKLYQ | ||||||
Motif | 226-230 | L/FRRG motif | ||||
Sequence: FRRGS | ||||||
Repeat | 230-269 | WD 5 | ||||
Sequence: SMPSRIFSMSFNTTSTLLCVSSSTETIHLFKLSQQTSSSR | ||||||
Compositional bias | 261-295 | Polar residues | ||||
Sequence: LSQQTSSSRDTSPSSSTPAGRDRAFSQSSLGHSPD | ||||||
Region | 261-314 | Disordered | ||||
Sequence: LSQQTSSSRDTSPSSSTPAGRDRAFSQSSLGHSPDRSDVSGEPDSSEFPARKHN | ||||||
Repeat | 312-358 | WD 6 | ||||
Sequence: KHNGTLMGIIRRTSQNVGSTVAAKVGGYLPKGVSEMWEPARDFAWIK | ||||||
Repeat | 370-410 | WD 7 | ||||
Sequence: GNNGPLRSVVAMSNNTPQVMVITSDGNFYVFSIDLSKGGEG |
Domain
The N-terminus might form a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane.
The L/FRRG motif is essential for the cytoplasm to vacuole transport (Cvt) pathway, for the recruitment of atg8 and atg16 to the PAS in nutrient-rich medium, and for its recruitment to and dissociation from the PAS under starvation conditions.
Sequence similarities
Belongs to the WD repeat PROPPIN family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length417
- Mass (Da)45,374
- Last updated2007-01-23 v1
- ChecksumB5B5B357E80423F2
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 261-295 | Polar residues | ||||
Sequence: LSQQTSSSRDTSPSSSTPAGRDRAFSQSSLGHSPD |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DS027049 EMBL· GenBank· DDBJ | EAW13036.1 EMBL· GenBank· DDBJ | Genomic DNA |