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A1CA18 · CARA_ASPCL

Function

function

Small subunit of the arginine-specific carbamoyl phosphate synthase (CPSase). CPSase catalyzes the formation of carbamoyl phosphate from the ammonia moiety of glutamine, carbonate, and phosphate donated by ATP, the first step of the arginine biosynthetic pathway. The small subunit (glutamine amidotransferase) binds and cleaves glutamine to supply the large subunit with the substrate ammonia.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site295Nucleophile
Active site379
Active site381

GO annotations

AspectTerm
Cellular Componentcarbamoyl-phosphate synthase complex
Cellular Componentmitochondrial matrix
Molecular FunctionATP binding
Molecular Functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Molecular Functionglutaminase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Processarginine biosynthetic process
Biological Processglutamine metabolic process
Biological Processpyrimidine nucleotide biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Carbamoyl phosphate synthase arginine-specific small chain
  • EC number
  • Short names
    CPS; CPSase
  • Alternative names
    • Arginine-specific carbamoyl phosphate synthetase, glutamine chain
    • Glutamine-dependent carbamoyl phosphate synthetase

Gene names

    • Name
      cpa1
    • ORF names
      ACLA_010090

Organism names

Accessions

  • Primary accession
    A1CA18

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for transit peptide, chain.

Type
IDPosition(s)Description
Transit peptide1-28Mitochondrion
ChainPRO_000029058629-455Carbamoyl phosphate synthase arginine-specific small chain

Interaction

Subunit

Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain219-406Glutamine amidotransferase type-1

Sequence similarities

Belongs to the CarA family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    455
  • Mass (Da)
    49,703
  • Last updated
    2007-01-23 v1
  • MD5 Checksum
    2EF5A55B56DB610FA7812B5FC7D77418
MFARFCKAIPAKGRAFPSVNASIQSRLMATVRNQRVPHERATFTIRDGPIFHGKSFGARTNISGEAVFTTSLVGYPESLTDPSYRGQILVFTQPLIGNYGVPSAERDQHGLLKYFESPHLQAAGVVVADVAEQYSHWTAVESLGEWCAREGVPAISGVDTRAIVTYLREQGSSLARITVGEEYDADQDEAFTDPEQIHLVRQVSTKAPFHVSAADPQCHVAVIDCGVKENILRSLVSRGASITVFPFDYPIHKVAHHFDGVFISNGPGDPTHCQDTTYHLRRLMETSQVPIFGICLGHQLLALAAGARTIKLKYGNRAHNIPALDMSTGRCHITSQNHGYAVDVDTLPSDWKPYFVNLNDSSNEGMIHKSRPIFSTQFHPEAKGGPLDSSYLFDIYIDSVRKYKANQAAFHPQRDSIPSPLLVDLLAKERVGVQPTIGMQNVQAAAAAAAVAAAA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS027049
EMBL· GenBank· DDBJ
EAW12586.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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