A1C2W1 · A1C2W1_MICGI

Function

function

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.

Cofactor

Protein has several cofactor binding sites:
heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 2 heme groups non-covalently.
heme (UniProtKB | Rhea| CHEBI:30413 )

Note: Binds 2 heme groups non-covalently.

Features

Showing features for binding site.

137950100150200250300350
TypeIDPosition(s)Description
Binding site83Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site97Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site182Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site196Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site201a ubiquinone (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex III
Molecular Functionmetal ion binding
Molecular Functionubiquinol-cytochrome-c reductase activity
Biological Processmitochondrial electron transport, ubiquinol to cytochrome c

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome b

Gene names

    • Name
      cyb

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Strepsirrhini > Lemuriformes > Cheirogaleidae > Microcebus

Accessions

  • Primary accession
    A1C2W1

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane30-57Helical
Transmembrane78-98Helical
Transmembrane113-133Helical
Transmembrane140-158Helical
Transmembrane178-200Helical
Transmembrane229-247Helical
Transmembrane288-307Helical
Transmembrane319-339Helical
Transmembrane345-372Helical

Keywords

Interaction

Subunit

The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-209Cytochrome b/b6 N-terminal region profile
Domain210-379Cytochrome b/b6 C-terminal region profile

Sequence similarities

Belongs to the cytochrome b family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    379
  • Mass (Da)
    42,750
  • Last updated
    2007-01-23 v1
  • Checksum
    F3BA233C5188B233
MTNIRKTHPLMKIMNSSFIDLPAPSNISSWWNFGSLLGACLTIQIITGLFLAMHYTADTTTAFSSVTHICRDVNQGWIIRYLHANGASMFFLCLFLHVGRGMYYGSFTLSETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPFIGTDLVEWIWGGFSVDKATLTRFFAFHFILPFIVSALVMVHLLFLHETGSNNPLGTPSESDKIPFHPYYTIKDLLGLMFLLLTLMMLVLFSPDLLGDPDNYMPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALIMSILILAIIPMLQTAKQRSMTFRPLSQITFWILTADLFILTWIGGQPVEYPFITIGQVASILYFSLILIIMPTVSLIENKMLKW

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ979892
EMBL· GenBank· DDBJ
ABK91732.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp