A1ANN6 · A1ANN6_PELPD

Function

function

Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

Catalytic activity

Cofactor

biotin (UniProtKB | Rhea| CHEBI:57586 )

Features

Showing features for binding site, active site.

111481002003004005006007008009001,0001,100
TypeIDPosition(s)Description
Binding site121ATP (UniProtKB | ChEBI)
Binding site205ATP (UniProtKB | ChEBI)
Binding site240ATP (UniProtKB | ChEBI)
Active site297
Binding site545Mn2+ (UniProtKB | ChEBI)
Binding site617substrate
Binding site714Mn2+ (UniProtKB | ChEBI); via carbamate group
Binding site743Mn2+ (UniProtKB | ChEBI)
Binding site745Mn2+ (UniProtKB | ChEBI)
Binding site878substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionpyruvate carboxylase activity
Biological Processgluconeogenesis
Biological Processpyruvate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pyruvate carboxylase
  • EC number

Gene names

    • Ordered locus names
      Ppro_1336

Organism names

Accessions

  • Primary accession
    A1ANN6

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue714N6-carboxylysine
Modified residue1114N6-biotinyllysine

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-458Biotin carboxylation
Domain125-322ATP-grasp
Domain536-804Pyruvate carboxyltransferase
Domain1073-1148Lipoyl-binding

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,148
  • Mass (Da)
    127,256
  • Last updated
    2007-01-23 v1
  • Checksum
    D5E58F273A29B9DC
MQKRKFKKIMAANRGEISVRIFRACAELGIRMVAIYSEEDKLSLHRYKADEAYLIGKGKAPVEAYLGIDEIIALALKVGVEAIHPGYGFLSENAEFAEKCEANGIVFIGPTGEMQRALGDKVAGRKMATAAGVNVVPGTEDPIEREEDALKFAKQYGYPIIVKAAAGGGGRGMRVAHNQKELLEGLVAAGSEAKAAFGNAAVFLERYLENPKHIEVQVLGDNYGNLVHFFERDCSVQRRHQKVVEFAPSLCITPELREELCDAALKIARQVNYRNAGTVEFLVDQQGRYYFMEMNPRIQVEHTVTEMITGRNLVQNQILVAGGYALSDPEINIPSQGAINMRGYAIQCRVTTEDPANNFAPDFGMLTTYRSAAGCGVRLDAGNATTGARITPHYDSLLVKVGTWGLTFPEAAHIMDRALREFRIRGVKTNIAFLENVVTHPVFLEGKCDTSFIDKHPELLVFEERKDRASKLLNYLGEVVVNGIPGITERMKSSQLAEARVPEVDVLSPRPQGTRDLFRKMGAEAFCTWVLEQERLFLTDTSMRDAHQSNLATRVRSYDLLKIAEPTSYLGAELFSLECWGGATFDVSMRFLKEDPWQRLHALSEKVPNVLLQMLLRGSNAVGYTNYPDNVVERFVDEAARSGIDVFRVFDSLNWTTGMQVAMEAVRKTGKICEAAICYTGDITDPKRDKYPLEYYVNLAKELEKMGAHILAIKDMAGLLKPFAAYRLIKALKENIGIPVHLHTHDTSSNGGATLLKASEAGVDIVDAALSALSGLTAQPSLNAIASALEGSERDPLVNGRGLQQLSNYWETVRDYYAPFESGLKGGTAEVYEHEIPGGQYSNFKPQVAGMGLIDRWEECKEMYRKVNLLFGDIVKVTPTSKVVGDMAMFLVKNNMQPEDIYTAREELAFPESVVGMFKGMLGQPHQGWPADLQRIILKGEQPITCRPGELLQPIDFQEERRKLEEKLGHPVDDKALLSAILYPNVYPDFDKHLQKYSDTSVIPTPIFFYGLEPGQETSLDIEPGKTLIIALNAIGRLHDDGTRVVSFSLNGNNRSVIIRDRSVTSGVFVRDKADRDNPSHIGAPMPGKVFKVNVKPGFEVKAGDVLMVTEAMKMETNIKAKVDGRVMEVKFKEGDKVEKDDLLIVMG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000482
EMBL· GenBank· DDBJ
ABK98956.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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