A0ZSF4 · MAP1_MIZYE

Function

function

Acts as a negative regulator for calcification in the shells of mollusks. May function both as a calcium concentrator and as a carbonic anhydrase required for production of carbonate ions, which are assembled to CaCO3 at mineralization sites. Is important for shell formation in both the calcitic prismatic layer and the aragonitic nacreous layer (By similarity).
Shows inhibitory activity of crystal formation when present in free state but, when attached to the insoluble matrix, may regulate the form and size of aragonite crystal

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Features

Showing features for binding site.

133150100150200250300
TypeIDPosition(s)Description
Binding site69Zn2+ (UniProtKB | ChEBI); catalytic
Binding site71Zn2+ (UniProtKB | ChEBI); catalytic
Binding site94Zn2+ (UniProtKB | ChEBI); catalytic
Binding site298-299substrate

GO annotations

AspectTerm
Cellular Componentextracellular region
Molecular Functioncarbonate dehydratase activity
Molecular Functionzinc ion binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Organism names

Accessions

  • Primary accession
    A0ZSF4

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003797931-331Nacrein-like protein P1

Keywords

Expression

Tissue specificity

Expressed in the mantle.

Interaction

Subunit

Homooligomer; disulfide-linked. May also be disulfide-linked to insoluble organic matrix (By similarity).

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias, repeat.

TypeIDPosition(s)Description
Domain1-331Alpha-carbonic anhydrase
Region138-240Disordered
Compositional bias141-157Basic and acidic residues
Compositional bias158-231Polar residues
Repeat162-1641
Region162-23324 X 3 AA approximate tandem repeats of G-X-N
Repeat165-1672
Repeat168-1703
Repeat171-1734
Repeat174-1765
Repeat177-1796
Repeat180-1827
Repeat183-1858
Repeat186-1889
Repeat189-19110
Repeat192-19411
Repeat195-19712
Repeat198-20013
Repeat201-20314
Repeat204-20615
Repeat207-20916
Repeat210-21217
Repeat213-21518
Repeat216-21819
Repeat219-22120
Repeat222-22421
Repeat225-22722
Repeat228-22923
Repeat231-23324

Domain

The Gly-Xaa-Asn repeat domain binds calcium.

Sequence similarities

Belongs to the alpha-carbonic anhydrase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    331
  • Mass (Da)
    36,918
  • Last updated
    2007-01-23 v1
  • Checksum
    48E96EDDB73DCDAB
QSPINIVSYDAKFRQRLPKLKFKPHMEKLKTEVTNHQNRAPEFEPEDGENLYVKLNNLVDGHYKFHNLHVHNGRTRRKGSEHSVNGRFTPMEAHLVFHHDDQTHFEPTRTKLGGAFPGHNDFVVVGVFLEVGDDGFGDEPDDEECKRILKGHHPDNNENGNGDNGNNGYNGDNGNNGDNGNNGYNGDNGNNGDNGNNGYNGDNGNNGDNGNNGENGNNGENGNNGENGNNGENGHKHGCRVKKAKHLSTILECAYRNDKVREFKKVGEEEGLDVHLTPEMPLPPLKNRHYYTYEGSLTTPPCTESVLWVVQKCHVQVSRRVLHALRNVEGY

Features

Showing features for non-terminal residue, compositional bias.

TypeIDPosition(s)Description
Non-terminal residue1
Compositional bias141-157Basic and acidic residues
Compositional bias158-231Polar residues
Non-terminal residue331

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB252481
EMBL· GenBank· DDBJ
BAF42331.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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