A0SVL1 · A0SVL1_RABIT

Function

function

Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentacrosomal vesicle
Cellular Componentadherens junction
Cellular Componentapicolateral plasma membrane
Cellular Componentbasolateral plasma membrane
Cellular Componentbicellular tight junction
Cellular Componentcell body
Cellular Componentfilopodium
Cellular Componentgrowth cone
Cellular Componentintercalated disc
Cellular Componentmembrane raft
Cellular Componentneuron projection
Cellular Componentnucleus
Cellular Componentplasma membrane
Molecular Functionbeta-catenin binding
Molecular Functioncell adhesion molecule binding
Molecular Functionconnexin binding
Molecular FunctionPDZ domain binding
Biological Processactin cytoskeleton organization
Biological ProcessAV node cell to bundle of His cell communication
Biological Processcardiac muscle cell development
Biological Processcell-cell junction organization
Biological Processepithelial structure maintenance
Biological Processgerm cell migration
Biological Processheart development
Biological Processheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
Biological Processhomotypic cell-cell adhesion
Biological Processmitochondrion organization
Biological Processneutrophil chemotaxis

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Coxsackie virus and adenovirus receptor

Gene names

    • Name
      CXADR

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Leporidae > Oryctolagus

Accessions

  • Primary accession
    A0SVL1

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane239-260Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-19
ChainPRO_500263051820-365

Keywords

Structure

Family & Domains

Features

Showing features for domain, compositional bias, region.

Type
IDPosition(s)Description
Domain33-136Ig-like
Domain141-216Ig-like
Compositional bias269-285Basic and acidic residues
Region269-309Disordered
Compositional bias286-309Polar residues

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    365
  • Mass (Da)
    40,176
  • Last updated
    2007-01-09 v1
  • MD5 Checksum
    13201F6D172762A2A95CC869CEBDD5DB
MALLLRFVLLCGVADFARSLTIINPEQMIEKAKGETAYLPCKFTVSDEDQGPLDIEWLLSPADNQKPDQVIILYSGDKIYVDYYQDLKGRVHFTSNDITSGDASINVTNLQLSDIGIYQCKVKKAPGVANKKVQLTVLVKPSGIRCFIDGSEEIGNDFKLKCEPKEGSLPLRYEWQKLSDSQKMPDSWLPEMTSPVISVKNATSEYSGTYSCTVRNRVGSDQCLLRLDVVPPSNRAGTIAGAIIGTLLALVLIGCIVFCCHKKRREEKYEKEVHHDIREDVPPPKSRTSTARSYIGSNHSSLGSMSPSNMEGYSKTLYNQVPSEDFERAPQSPTLPPAKVAAPNLSRMGAVPVMIPAQSKDGSIV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias269-285Basic and acidic residues
Compositional bias286-309Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EF034116
EMBL· GenBank· DDBJ
ABK58723.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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