A0SBX2 · A0SBX2_HUMAN

  • Protein
    ATP synthase subunit a
  • Gene
    ATP6
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentproton-transporting ATP synthase complex, coupling factor F(o)
Molecular Functionproton transmembrane transporter activity
Biological Processproton motive force-driven ATP synthesis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    ATP synthase subunit a

Gene names

    • Name
      ATP6

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • TZBG034_L0f
    • Tzdt004_M1a
    • TZGG017_L0f
    • Tztr037_L2a
    • MUN55
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0SBX2

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein
Mitochondrion membrane

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-31Helical
Transmembrane67-86Helical
Transmembrane98-117Helical
Transmembrane137-158Helical
Transmembrane164-184Helical
Transmembrane191-222Helical

Keywords

PTM/Processing

Proteomic databases

Interaction

Subunit

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ. Interacts with DNAJC30; interaction is direct.

Family & Domains

Sequence similarities

Belongs to the ATPase A chain family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    226
  • Mass (Da)
    24,787
  • Last updated
    2007-01-09 v1
  • Checksum
    820B44A43D54520B
MNENLFASFIAPTILGLPAAVLIILFPPLLIPTSKYLINNRLITTQQWLIKLTSKQMMAMHNTKGRTWSLMLVSLIIFIATTNLLGLLPHSFTPTTQLSMNLAMAIPLWAGAVIMGFRSKIKNALAHFLPQGTPTPLIPMLVIIETISLLIQPMALAVRLTANITAGHLLMHLIGSTTLAMSTINLPSTLIIFTILILLTILEIAVALIQAYVFTLLVSLYLHDNT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ304997
EMBL· GenBank· DDBJ
ABB98860.1
EMBL· GenBank· DDBJ
Genomic DNA
EF184598
EMBL· GenBank· DDBJ
ABO39457.1
EMBL· GenBank· DDBJ
Genomic DNA
EF184600
EMBL· GenBank· DDBJ
ABO39483.1
EMBL· GenBank· DDBJ
Genomic DNA
EF184620
EMBL· GenBank· DDBJ
ABO39739.1
EMBL· GenBank· DDBJ
Genomic DNA
EF184635
EMBL· GenBank· DDBJ
ABO39934.1
EMBL· GenBank· DDBJ
Genomic DNA
EU443505
EMBL· GenBank· DDBJ
ACA01184.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ383291
EMBL· GenBank· DDBJ
ACM70914.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ383689
EMBL· GenBank· DDBJ
ACM76088.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ383690
EMBL· GenBank· DDBJ
ACM76101.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ383691
EMBL· GenBank· DDBJ
ACM76114.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ383692
EMBL· GenBank· DDBJ
ACM76127.1
EMBL· GenBank· DDBJ
Genomic DNA
GQ301872
EMBL· GenBank· DDBJ
ACT15755.1
EMBL· GenBank· DDBJ
Genomic DNA
GQ337643
EMBL· GenBank· DDBJ
ACU10930.1
EMBL· GenBank· DDBJ
Genomic DNA
GU810024
EMBL· GenBank· DDBJ
ADD53296.1
EMBL· GenBank· DDBJ
Genomic DNA
GU810039
EMBL· GenBank· DDBJ
ADD53491.1
EMBL· GenBank· DDBJ
Genomic DNA
GU810043
EMBL· GenBank· DDBJ
ADD53543.1
EMBL· GenBank· DDBJ
Genomic DNA
GU810054
EMBL· GenBank· DDBJ
ADD53686.1
EMBL· GenBank· DDBJ
Genomic DNA
HM030508
EMBL· GenBank· DDBJ
ADE33187.1
EMBL· GenBank· DDBJ
Genomic DNA
HM030541
EMBL· GenBank· DDBJ
ADE33616.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ541751
EMBL· GenBank· DDBJ
ADQ52520.1
EMBL· GenBank· DDBJ
Genomic DNA
JF824857
EMBL· GenBank· DDBJ
AEG62694.1
EMBL· GenBank· DDBJ
Genomic DNA
JF824950
EMBL· GenBank· DDBJ
AEG63903.1
EMBL· GenBank· DDBJ
Genomic DNA
JF742213
EMBL· GenBank· DDBJ
AEH04085.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ044960
EMBL· GenBank· DDBJ
AEV49052.1
EMBL· GenBank· DDBJ
Genomic DNA
JX669209
EMBL· GenBank· DDBJ
AFV54435.1
EMBL· GenBank· DDBJ
Genomic DNA
KC345764
EMBL· GenBank· DDBJ
AGD81892.1
EMBL· GenBank· DDBJ
Genomic DNA
KC345779
EMBL· GenBank· DDBJ
AGD82087.1
EMBL· GenBank· DDBJ
Genomic DNA
KF540714
EMBL· GenBank· DDBJ
AGZ08579.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ154544
EMBL· GenBank· DDBJ
AHW34736.1
EMBL· GenBank· DDBJ
Genomic DNA
KM101667
EMBL· GenBank· DDBJ
AIU58375.1
EMBL· GenBank· DDBJ
Genomic DNA
KP313555
EMBL· GenBank· DDBJ
AJM70289.1
EMBL· GenBank· DDBJ
Genomic DNA
KT725881
EMBL· GenBank· DDBJ
ANA92262.1
EMBL· GenBank· DDBJ
Genomic DNA
KX467322
EMBL· GenBank· DDBJ
ANU81086.1
EMBL· GenBank· DDBJ
Genomic DNA
KU683227
EMBL· GenBank· DDBJ
AOR45887.1
EMBL· GenBank· DDBJ
Genomic DNA
KU683511
EMBL· GenBank· DDBJ
AOR49579.1
EMBL· GenBank· DDBJ
Genomic DNA
KX456534
EMBL· GenBank· DDBJ
APD53977.1
EMBL· GenBank· DDBJ
Genomic DNA
MF055992
EMBL· GenBank· DDBJ
ASR96827.1
EMBL· GenBank· DDBJ
Genomic DNA
MF056054
EMBL· GenBank· DDBJ
ASR97633.1
EMBL· GenBank· DDBJ
Genomic DNA
MF056329
EMBL· GenBank· DDBJ
ASS01209.1
EMBL· GenBank· DDBJ
Genomic DNA
MF057198
EMBL· GenBank· DDBJ
ASS12481.1
EMBL· GenBank· DDBJ
Genomic DNA
MF057450
EMBL· GenBank· DDBJ
ASS15757.1
EMBL· GenBank· DDBJ
Genomic DNA
MF057455
EMBL· GenBank· DDBJ
ASS15822.1
EMBL· GenBank· DDBJ
Genomic DNA
MF057855
EMBL· GenBank· DDBJ
ASS21205.1
EMBL· GenBank· DDBJ
Genomic DNA
MF058144
EMBL· GenBank· DDBJ
ASS24949.1
EMBL· GenBank· DDBJ
Genomic DNA
MF058404
EMBL· GenBank· DDBJ
ASS28329.1
EMBL· GenBank· DDBJ
Genomic DNA
MF058524
EMBL· GenBank· DDBJ
ASS29798.1
EMBL· GenBank· DDBJ
Genomic DNA
MG272775
EMBL· GenBank· DDBJ
AVL87500.1
EMBL· GenBank· DDBJ
Genomic DNA
MH449123
EMBL· GenBank· DDBJ
AYW06313.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849795
EMBL· GenBank· DDBJ
QKT25874.1
EMBL· GenBank· DDBJ
Genomic DNA
MW467860
EMBL· GenBank· DDBJ
QTK30092.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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