A0RLA2 · UPP_BACAH

Function

function

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.

Activity regulation

Allosterically activated by GTP.

Pathway

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site795-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site1045-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site131-1395-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site194uracil (UniProtKB | ChEBI)
Binding site199-201uracil (UniProtKB | ChEBI)
Binding site2005-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Molecular Functionuracil phosphoribosyltransferase activity
Biological ProcessUMP salvage
Biological Processuracil salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uracil phosphoribosyltransferase
  • EC number
  • Alternative names
    • UMP pyrophosphorylase
    • UPRTase

Gene names

    • Name
      upp
    • Ordered locus names
      BALH_4815

Organism names

Accessions

  • Primary accession
    A0RLA2

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000536761-209Uracil phosphoribosyltransferase

Structure

Family & Domains

Sequence similarities

Belongs to the UPRTase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    209
  • Mass (Da)
    22,902
  • Last updated
    2007-01-09 v1
  • MD5 Checksum
    1EB207FBA5692E2C2EF77D6005A60C99
MGKLYVFDHPLIQHKITYIRDKNTGTKDFRELVDEVASLMAFEITRDLPLEDIEIETPVSKATTKVIAGKKLGLIPILRAGLGMVDGILKLIPAAKVGHVGLYRDPKTLQPVEYYVKLPTDVEERDFIVLDPMLATGGSAAEAINSLKKRGAKQIKLMCIVAAPEGVKVVQEEHPDVDIYVAALDEKLNDHGYVVPGLGDAGDRLFGTK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000485
EMBL· GenBank· DDBJ
ABK87995.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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