A0R609 · KATG1_MYCS2
- ProteinCatalase-peroxidase 1
- GenekatG1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids739 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. May play a role in the intracellular survival of mycobacteria.
Catalytic activity
- AH2 + H2O2 = A + 2 H2O
Cofactor
Note: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
Features
Showing features for site, active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | catalase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | hydrogen peroxide catabolic process | |
Biological Process | response to oxidative stress |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameCatalase-peroxidase 1
- EC number
- Short namesCP 1
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycolicibacterium
Accessions
- Primary accessionA0R609
- Secondary accessions
Proteomes
Phenotypes & Variants
Disruption phenotype
Defects cause isoniazid (INH) resistance.
PTM/Processing
Features
Showing features for chain, cross-link.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000293596 | 1-739 | Catalase-peroxidase 1 | |||
Sequence: MPEDRPIEDSPPIGEAQTDAPAGGCPAGFGRIKPPVAGGSNRDWWPNQLNLKILQKNPDVINPLDEDFDYRSAVQNLDVDALRADIVEVMHTSQDWWPADFGHYGPLFIRMAWHAAGTYRVSDGRGGAGAGMQRFAPLNSWPDNASLDKARRLLWPVKKKYGKNLSWADLIVYAGNVALEDMGFRTAGFAFGREDRWEPEEDVYWGPEQEWLDDKRYTGERDLENPLAAVQMGLIYVNPEGPNGNPDPQASAIDIRETFGRMAMNDVETAALIVGGHTFGKTHGNGDASLVGPEPEAAPLEEVGLGWRNPQGTGVGKDAITSGLEVTWTHTPTKWDNSFLEILYGNEWELTKSPAGANQWKPKDNGWANSVPLAHEDGKTHPSMLTSDLALRVDPIYEQITRRWLDHPEELAEEFAKAWFKLLHRDMGPVTRYLGPEVPKDTWLWQDNIPAGNDLSDDEVAKLKELIADSGLTVSQLVSTAWKAASTFRSSDLRGGANGGRIRLQPQLGWEANEPDELAQVVRKYEEIQKASGINVSFADLVVLGGNVGVEKAAKAAGFDVTVPFTPGRGDATQEETDVDSFAYLEPKADGFRNYLGKGSDLPAEFKLIDRANLLGLSAPEMTTLVGGLRVLDVNHGGTKHGVLTDKPGALTTDFFVNLLDMSTAWKPSPADDGTYIGTDRATGSPKWTGTRVDLVFASNSQLRALAEVYAEDDSKEKFVKDFVAAWTKVMDADRFDVA | ||||||
Cross-link | 113↔236 | Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-262) | ||||
Sequence: WHAAGTYRVSDGRGGAGAGMQRFAPLNSWPDNASLDKARRLLWPVKKKYGKNLSWADLIVYAGNVALEDMGFRTAGFAFGREDRWEPEEDVYWGPEQEWLDDKRYTGERDLENPLAAVQMGLIY | ||||||
Cross-link | 236↔262 | Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-113) | ||||
Sequence: YVNPEGPNGNPDPQASAIDIRETFGRM |
Post-translational modification
Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
Proteomic databases
Interaction
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-33 | Disordered | ||||
Sequence: MPEDRPIEDSPPIGEAQTDAPAGGCPAGFGRIK |
Sequence similarities
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length739
- Mass (Da)81,115
- Last updated2007-01-09 v1
- Checksum5E87F6B884D832ED
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 374-378 | in Ref. 1; CAA67268 | ||||
Sequence: AHEDG → PTRTA |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X98718 EMBL· GenBank· DDBJ | CAA67268.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP000480 EMBL· GenBank· DDBJ | ABK73944.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP001663 EMBL· GenBank· DDBJ | AFP42642.1 EMBL· GenBank· DDBJ | Genomic DNA |