A0R4H4 · Y5835_MYCS2

Function

function

Able to catalyze the elimination of the C-1 and C-2 hydrogen atoms of the A-ring from the polycyclic ring structure of 3-ketosteroids, but the ketosteroid dehydrogenase activity is low compared to KsdD in the cholesterol degradation process. The low activity could be due to different substrate specificity.

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Pathway

Lipid metabolism; steroid biosynthesis.

Features

Showing features for binding site.

154750100150200250300350400450500
TypeIDPosition(s)Description
Binding site5-36FAD (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functionsteroid dehydrogenase activity, acting on the CH-CH group of donors
Biological Processlipid catabolic process
Biological Processsteroid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    KsdD-like steroid dehydrogenase MSMEG_5835
  • EC number

Gene names

    • Ordered locus names
      MSMEG_5835, MSMEI_5677

Organism names

Accessions

  • Primary accession
    A0R4H4
  • Secondary accessions
    • I7G8Z6

Proteomes

Phenotypes & Variants

Disruption phenotype

Cells accumulate a small amount of 4-androstene-3,17-dione (AD) and 9alpha-hydroxy-4-androstene-3,17-dione (9OHAD) in the first 24-48 hours of cholesterol degradation process.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004039541-547KsdD-like steroid dehydrogenase MSMEG_5835

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    547
  • Mass (Da)
    59,024
  • Last updated
    2007-01-09 v1
  • Checksum
    0F43A352A91799CC
MADADVIVVGAGLAGLVAACELVERGHSVIIVDQENAANIGGQAFWSFGGLFFVNSPEQRRLGIRDSQELALQDWLGTAGFDRPEDHWPREWAHAYVDFAAGEKRSWLRARGLQTFPLVGWAERGGYDALGHGNSVPRFHITWGTGPALVEIFARRIRDSVRVRFAHRHRVDELIVNAGLVAGVRGSILEPSNAPRGVASSRKVVGDFEFRASAVIVASGGIGGNLELVRKNWPARLGRVPDQLISGVPAHVDGRMIGIAESAGAHVINNDRMWHYTEGITNYDPVWPNHGIRILPGPSSLWLDANGDRLPVPLYPGYDTLGTLEHICRSGQDYTWFILNARIIAKEFALSGQEQNPDLTSRNVRDLLSRVKPGAPAPVQAFVDHGVDFVSATSLRDLVAGMNDLPDVVPLDYAKVAAEVTARDREVANRFTKDGQITAIRAARNYLGDRFTRVVAPHRLTDPKAGPLIAVKLHILTRKTLGGLETDLDSRVLKEDGTTFGGLYAAGEAAGFGGGGVHGYRSLEGTFLGGCIFSGRAAGRGAAADIA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000480
EMBL· GenBank· DDBJ
ABK72138.1
EMBL· GenBank· DDBJ
Genomic DNA
CP001663
EMBL· GenBank· DDBJ
AFP42112.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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