A0R2W4 · ZFPP_MYCS2
- Protein(2Z,6E)-farnesyl diphosphate synthase
- GeneuppS
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids263 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Catalyzes the condensation of only one isopentenyl pyrophosphate (IPP) unit in the cis configuration to E-geranyl diphosphate (E-GPP) generating the 15 carbon product (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall.
Catalytic activity
- isopentenyl diphosphate + (2E)-geranyl diphosphate = (2Z,6E)-farnesyl diphosphate + diphosphate
Cofactor
Note: Binds 2 magnesium ions per subunit.
Features
Showing features for active site, binding site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 40 | ||||
Binding site | 40 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 41-44 | substrate | |||
Binding site | 45 | substrate | |||
Site | 84 | Important for determining product length | |||
Binding site | 86-88 | substrate | |||
Active site | 89 | Proton acceptor | |||
Binding site | 92 | substrate | |||
Binding site | 212 | substrate | |||
Binding site | 218-220 | substrate | |||
Binding site | 231 | Mg2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | magnesium ion binding | |
Molecular Function | polyprenyltransferase activity | |
Molecular Function | Z-farnesyl diphosphate synthase activity | |
Biological Process | polyprenol biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name(2Z,6E)-farnesyl diphosphate synthase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycolicibacterium
Accessions
- Primary accessionA0R2W4
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000417571 | 1-263 | (2Z,6E)-farnesyl diphosphate synthase | ||
Proteomic databases
Interaction
Structure
Sequence
- Sequence statusComplete
- Length263
- Mass (Da)29,935
- Last updated2007-01-09 v1
- ChecksumC22ABBD9F9A6EF1F
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000480 EMBL· GenBank· DDBJ | ABK70340.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP001663 EMBL· GenBank· DDBJ | AFP41562.1 EMBL· GenBank· DDBJ | Genomic DNA |