A0R2W4 · ZFPP_MYCS2

Function

function

Catalyzes the condensation of only one isopentenyl pyrophosphate (IPP) unit in the cis configuration to E-geranyl diphosphate (E-GPP) generating the 15 carbon product (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 magnesium ions per subunit.

Features

Showing features for active site, binding site, site.

Type
IDPosition(s)Description
Active site40
Binding site40Mg2+ (UniProtKB | ChEBI)
Binding site41-44substrate
Binding site45substrate
Site84Important for determining product length
Binding site86-88substrate
Active site89Proton acceptor
Binding site92substrate
Binding site212substrate
Binding site218-220substrate
Binding site231Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionmagnesium ion binding
Molecular Functionpolyprenyltransferase activity
Molecular FunctionZ-farnesyl diphosphate synthase activity
Biological Processpolyprenol biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    (2Z,6E)-farnesyl diphosphate synthase
  • EC number
  • Alternative names
    • Short-chain Z-isoprenyl diphosphate synthase
    • Z-FPP synthase (Z-FPPS)
    • Z-Polyprenyl diphosphate synthase
    • Z-isoprenyl diphosphate synthase

Gene names

    • Name
      uppS
    • Ordered locus names
      MSMEG_5256, MSMEI_5118

Organism names

Accessions

  • Primary accession
    A0R2W4
  • Secondary accessions
    • I7G761

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004175711-263(2Z,6E)-farnesyl diphosphate synthase

Proteomic databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    263
  • Mass (Da)
    29,935
  • Last updated
    2007-01-09 v1
  • Checksum
    C22ABBD9F9A6EF1F
MDIIPPRLKEPAYRIYEMRLRHELVRSKAQLPRHIAVLCDGNRRWARDAGYDDVSIGYRKGAAKIAEMLRWCQAAGIEMATIYLLSTENLQRDPDELTALIEIITDVVEEICAPYNKWSVRTVGDLELLGDEPARRLREAVESTTTKGANFHVNVAVAYGGRQEIVDAVRSLLSKELANGATAEQLIEAVTVDGISENLYTSGQPDPDLVIRTSGEQRLSGFLLWQSAYSEMWFTEAYWPAFRRVDFLRALRDYTARHRRFGK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000480
EMBL· GenBank· DDBJ
ABK70340.1
EMBL· GenBank· DDBJ
Genomic DNA
CP001663
EMBL· GenBank· DDBJ
AFP41562.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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