A0R006 · WAG31_MYCS2

Function

function

Important for maintaining cell shape and cell wall integrity by localizing peptidoglycan synthesis to the cell poles. Protects PbpB (PBP3, FtsI) from oxidative stress-induced cleavage.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Biological Processcell division
Biological Processregulation of cell shape

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cell wall synthesis protein Wag31
  • Alternative names
    • Antigen 84

Gene names

    • Name
      wag31
    • Synonyms
      ag84
    • Ordered locus names
      MSMEG_4217, MSMEI_4119

Organism names

Accessions

  • Primary accession
    A0R006

Proteomes

Subcellular Location

Cytoplasm
Note: Localizes to the cell poles.

Keywords

Phenotypes & Variants

Disruption phenotype

Depletion causes a morphological change in which one end of the cell becomes round rather than rod-shaped. This phenotype is caused by the absence or dispersal of peptidoglycan synthesis.

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00004211561-272Cell wall synthesis protein Wag31
Modified residue74Phosphothreonine

Post-translational modification

Phosphorylated by PknA.

Keywords

Proteomic databases

Expression

Induction

Positively regulated by the stringent response.

Interaction

Subunit

Forms homooligomers (By similarity).
Interacts with PbpB and CwsA

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, coiled coil, compositional bias.

TypeIDPosition(s)Description
Region1-22Disordered
Coiled coil30-67
Region62-109Disordered
Compositional bias81-98Pro residues
Coiled coil139-206
Region243-272Disordered
Compositional bias251-272Polar residues

Sequence similarities

Belongs to the DivIVA family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    272
  • Mass (Da)
    29,544
  • Last updated
    2007-01-09 v1
  • Checksum
    3A6AFB2E22610461
MPLTPADVHNVAFSKPPIGKRGYNEDEVDAFLDLVENELTRLIEENADLRQRVAELDQELAAARSGAGASSQATSSIPLYEPEPEPAPAPPQPVYEAPAQPAAPQSEDTAVRAARVLSLAQDTADRLTSTAKAEADKLLSDARAQAEAMVSDARQTAETTVSEARQRADAMLADAQTRSEAQLRQAQEKADALQADAERKHSEIMGTINQQRTVLEGRLEQLRTFEREYRTRLKTYLESQLEELGQRGSAAPVDSSANSDASGFGQFNRGNN

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias81-98Pro residues
Compositional bias251-272Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000480
EMBL· GenBank· DDBJ
ABK72820.1
EMBL· GenBank· DDBJ
Genomic DNA
CP001663
EMBL· GenBank· DDBJ
AFP40576.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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