A0R006 · WAG31_MYCS2
- ProteinCell wall synthesis protein Wag31
- Genewag31
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids272 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Important for maintaining cell shape and cell wall integrity by localizing peptidoglycan synthesis to the cell poles. Protects PbpB (PBP3, FtsI) from oxidative stress-induced cleavage.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Biological Process | cell division | |
Biological Process | regulation of cell shape |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameCell wall synthesis protein Wag31
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycolicibacterium
Accessions
- Primary accessionA0R006
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Note: Localizes to the cell poles.
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Depletion causes a morphological change in which one end of the cell becomes round rather than rod-shaped. This phenotype is caused by the absence or dispersal of peptidoglycan synthesis.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000421156 | 1-272 | Cell wall synthesis protein Wag31 | |||
Sequence: MPLTPADVHNVAFSKPPIGKRGYNEDEVDAFLDLVENELTRLIEENADLRQRVAELDQELAAARSGAGASSQATSSIPLYEPEPEPAPAPPQPVYEAPAQPAAPQSEDTAVRAARVLSLAQDTADRLTSTAKAEADKLLSDARAQAEAMVSDARQTAETTVSEARQRADAMLADAQTRSEAQLRQAQEKADALQADAERKHSEIMGTINQQRTVLEGRLEQLRTFEREYRTRLKTYLESQLEELGQRGSAAPVDSSANSDASGFGQFNRGNN | ||||||
Modified residue | 74 | Phosphothreonine | ||||
Sequence: T |
Post-translational modification
Phosphorylated by PknA.
Keywords
- PTM
Proteomic databases
Expression
Induction
Positively regulated by the stringent response.
Interaction
Subunit
Forms homooligomers (By similarity).
Interacts with PbpB and CwsA
Interacts with PbpB and CwsA
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, coiled coil, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-22 | Disordered | ||||
Sequence: MPLTPADVHNVAFSKPPIGKRG | ||||||
Coiled coil | 30-67 | |||||
Sequence: AFLDLVENELTRLIEENADLRQRVAELDQELAAARSGA | ||||||
Region | 62-109 | Disordered | ||||
Sequence: AARSGAGASSQATSSIPLYEPEPEPAPAPPQPVYEAPAQPAAPQSEDT | ||||||
Compositional bias | 81-98 | Pro residues | ||||
Sequence: EPEPEPAPAPPQPVYEAP | ||||||
Coiled coil | 139-206 | |||||
Sequence: LSDARAQAEAMVSDARQTAETTVSEARQRADAMLADAQTRSEAQLRQAQEKADALQADAERKHSEIMG | ||||||
Region | 243-272 | Disordered | ||||
Sequence: ELGQRGSAAPVDSSANSDASGFGQFNRGNN | ||||||
Compositional bias | 251-272 | Polar residues | ||||
Sequence: APVDSSANSDASGFGQFNRGNN |
Sequence similarities
Belongs to the DivIVA family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length272
- Mass (Da)29,544
- Last updated2007-01-09 v1
- Checksum3A6AFB2E22610461
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 81-98 | Pro residues | ||||
Sequence: EPEPEPAPAPPQPVYEAP | ||||||
Compositional bias | 251-272 | Polar residues | ||||
Sequence: APVDSSANSDASGFGQFNRGNN |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000480 EMBL· GenBank· DDBJ | ABK72820.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP001663 EMBL· GenBank· DDBJ | AFP40576.1 EMBL· GenBank· DDBJ | Genomic DNA |