A0QYP1 · KATG3_MYCS2

Function

function

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.

Catalytic activity

Cofactor

heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.

Features

Showing features for site, active site, binding site.

TypeIDPosition(s)Description
Site103Transition state stabilizer
Active site107Proton acceptor
Binding site269Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncatalase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processcellular response to hydrogen peroxide
Biological Processhydrogen peroxide catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Catalase-peroxidase 3
  • EC number
  • Short names
    CP 3
  • Alternative names
    • Peroxidase/catalase 3

Gene names

    • Name
      katG3
    • Synonyms
      katG
    • Ordered locus names
      MSMEG_3729, MSMEI_3640

Organism names

Accessions

  • Primary accession
    A0QYP1
  • Secondary accessions
    • I7FN10

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain, cross-link.

TypeIDPosition(s)Description
ChainPRO_00003548401-744Catalase-peroxidase 3
Cross-link106↔228Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-254)
Cross-link228↔254Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-106)

Post-translational modification

Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.

Proteomic databases

Interaction

Subunit

Homodimer or homotetramer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the peroxidase family. Peroxidase/catalase subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    744
  • Mass (Da)
    82,295
  • Last updated
    2008-11-25 v2
  • Checksum
    A980D38FD8FCBF8E
MPESPDAYVNRTYDQTVAVRRSLKRRNSPAASEDGLGWPRRLNLRILAQPCRTSSPLGEDFDYAKEFLSLDLDELARDIDEVLTTSQDWWPADFGHYGPLVLRMAWHFAGTYRIGDGRGGAGAGMLRFAPLNSFPDNRNLDKARRLLWPVKKKYGRKISWSDLMIFAGNRALESMGCRTFGFAGGREDAWEADETYWGPESTWLADERHSGVRDLDQPLAASEMGLIYVDPQGPATLPDPLASARDIRETFRRMGMNDEETVALIAGGHTFGKSHGPTDPSRCLGPEPEGAPLEALGLGWVNSFGTGNGADTVTSGLDGIWTATPTKWDMSFLTTLFAYEWDVALSPAGMWQWVPRNGAGAGTVPDPYDPSRTHAPTMLTTDLALQEDPRYRVIALRFLENPDEFADTFARAWFKLTHIDMGPIQRYLGPLVPTERMIWQDPVPHVDHELADADDVAALKREILGSGLSVSQLVTTAWASASTFRNSDKRGGANGARIRLEPQRSWAVNEPEKLAIVLDRLERIRRRFNDSHRGGKQISAADLIMLGGCAAVEHAAAEAGHPIEVPCRLGRTDAPQEWTDIEWFSALEPTADAFRNYVGEGNRPPPEHLLVDRASQLTLTAPQMTVLLGGLRVLGANHGGSPLGVFTASPGALSNDFFVNLLDVNIEWTPRADTADWTAAYEGRDRRTGEVTWIASRVDLSFASDPVLRAISEVYASADAEEKFVRDFVSAWDKVMNLDLFDRT

Sequence caution

The sequence ABK74103.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence AFP40103.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000480
EMBL· GenBank· DDBJ
ABK74103.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation
CP001663
EMBL· GenBank· DDBJ
AFP40103.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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