A0QQF4 · TTFA_MYCS2

Function

function

Required for MmpL3-dependent trehalose monomycolate (TMM) transport to the cell wall. Required for growth and cell elongation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell septum
Cellular Componentcell tip
Cellular Componentplasma membrane
Biological Processcell wall organization
Biological Processlipid transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Trehalose monomycolate transport factor A
  • Alternative names
    • TMM transport factor A

Gene names

    • Name
      ttfA
    • Ordered locus names
      MSMEG_0736
      , MSMEI_0720

Organism names

Accessions

  • Primary accession
    A0QQF4
  • Secondary accessions
    • I7F6I5

Proteomes

Subcellular Location

Cell inner membrane
; Single-pass membrane protein
Cell septum
Cell tip
Note: Colocalizes with MmpL3 to the cell poles and septa. Trehalose monomycolate (TMM) synthesis is not required for localization to the poles or septa.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1Periplasmic
Transmembrane2-22Helical
Topological domain23-278Cytoplasmic

Keywords

Phenotypes & Variants

Disruption phenotype

Knockdown of this gene leads to cessation of growth and shorter misshapen cells. Accummulation of trehalose monomycolate (TMM) and lack of trehalose dimycolate (TDM). Accumulates MSMEG_5308 protein.

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis1-23No localization to poles or septa, loss of function complementation and interaction with MmpL3.
Mutagenesis24-278No localization to poles or septa, loss of function complementation and interaction with MmpL3.
Mutagenesis51-278No localization to poles or septa, loss of function complementation and interaction with MmpL3.
Mutagenesis101-278No localization to poles or septa, loss of function complementation and interaction with MmpL3.
Mutagenesis151-278No localization to poles or septa, loss of function complementation and interaction with MmpL3.
Mutagenesis206-278Localizes to poles and septa in a pattern similar to the wild-type. Complements function. Interacts with MmpL3.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004526031-278Trehalose monomycolate transport factor A

Proteomic databases

Interaction

Subunit

Monomer (PubMed:31833106).
Interacts (via N-terminus) with MmpL3; active trehalose monomycolate (TMM) biosynthesis is not required for the complex formation. Interacts with MSMEG_5308 (PubMed:31239378).

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region200-278Disordered
Compositional bias250-278Basic and acidic residues

Domain

The N-terminal domain (1-205) is necessary and sufficient for proper localization and function of this protein, and for its interaction with MmpL3.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    278
  • Mass (Da)
    31,196
  • Last updated
    2007-01-09 v1
  • Checksum
    B5CD4F2D3C2A7517
MVPLWFTLSALCFVGAAVLLYVDIDRRRGLGRRRKSWAKSHGFDYEYESEDLLKRWKRGVMSTVGDVTAKNVVLGQIRGEAVFIFDIEEVATVIALHRKVGTNVVVDLRLKGLKEPRENDIWLLGAIGPRMVYSTNLDAARRACDRRMVTFAHTAPDCAEIMWNEQNWTLVAMPVTSNRAQWDEGLRTVRQFNDLLRVLPPVPQNGSQAALPRRGGSPSRPLAPTPAGRRELPPGRADVPPARGDVSRFAPRPEAGRSDAFRRPPPARNGREASHFQR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias250-278Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000480
EMBL· GenBank· DDBJ
ABK72891.1
EMBL· GenBank· DDBJ
Genomic DNA
CP001663
EMBL· GenBank· DDBJ
AFP37200.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp