A0QNL0 · ECCE1_MYCS2

Function

function

Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB (PubMed:15687187).
Plays a role in DNA conjugation, in at least a donor strain (PubMed:15314236).

Miscellaneous

DNA conjugation in M.smegmatis is unidirectional with distinct donor and recipient strains; mc2155 is a donor strain while MKD8 is a recipient strain. Mutations in a donor strain that alter DNA transfer do not always alter DNA transfer in a recipient strain.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    ESX-1 secretion system protein EccE1

Gene names

    • Name
      eccE1
    • Synonyms
      Ms3382c
      , Sm3882c
      , snm7
    • Ordered locus names
      MSMEG_0082, MSMEI_0080

Organism names

Accessions

  • Primary accession
    A0QNL0

Proteomes

Subcellular Location

Cell inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane11-31Helical
Transmembrane34-54Helical

Keywords

Phenotypes & Variants

Disruption phenotype

Increases efficiency of DNA conjugation when disrupted in donor strain (PubMed:15314236).
Loss of secretion of EsxA and EsxB, but not their expression (PubMed:15687187).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004383501-464ESX-1 secretion system protein EccE1

Proteomic databases

Interaction

Subunit

Part of the ESX-1 / type VII secretion system (T7SS), which is composed of cytosolic and membrane components. The ESX-1 membrane complex is composed of EccB1, EccCa1, EccCb1, EccD1 and EccE1 (By similarity).

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the EccE family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    464
  • Mass (Da)
    51,023
  • Last updated
    2007-01-09 v1
  • Checksum
    0D46E52940406076
MNFLRQFGFRFTTGHGIWAATLIPACIAICMHFDLLWLGITLGALIALFSVLTIRGLRITGWVRAIFSWRRRHRSTPDIASEPAVGSTVMPGDHVAVRWQGDYLIAVIELVPRPFTPTVIVNGSAMTDDVVNTKLVERLLEAHCPDLEADVVSAGYRVGKTAPASLIALYEQVVGPYPAPANRRTWIVLRADPEKTQRSAHRRDSGVSGLARYLVASATRIADQLASNGVDARCCRSFDDYEKATEISYERETWSSIKGRSTFTAAYTAPGGPDMWWSARADHTITRVRVRPGAAPSSAILLTTLANPTTPRGFSCLFGGQRAALQGIVPVSDKHYDLPIGSAGVLVGETADRYPVYMPFDNVDVSINLGDARLFTQFVIRSAAAGAVVTLGPQFREFATMINGRVGRTPRIGWPNATTYLGPHQGVGRVILRPNFIDTPRHRQLPIQLINPREESRYQMALEQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000480
EMBL· GenBank· DDBJ
ABK70621.1
EMBL· GenBank· DDBJ
Genomic DNA
CP001663
EMBL· GenBank· DDBJ
AFP36562.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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