A0QJB7 · LEUC_MYCA1
- Protein3-isopropylmalate dehydratase large subunit
- GeneleuC
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids476 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Catalytic activity
- (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate
Cofactor
Note: Binds 1 [4Fe-4S] cluster per subunit.
Pathway
Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 3-isopropylmalate dehydratase activity | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | metal ion binding | |
Biological Process | L-leucine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-isopropylmalate dehydratase large subunit
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycobacterium > Mycobacterium avium complex (MAC)
Accessions
- Primary accessionA0QJB7
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000063572 | 1-476 | 3-isopropylmalate dehydratase large subunit | |||
Sequence: MGIDAGTTATPRTLAEKVWDDHVVVSGGANEPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLTLATEDHNVPTIDIDKPIADPVSRTQVETLRRNCAEFGVRLYPMGDAEQGIVHVVGPQLGLTQPGMTVVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGELPAGVTAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTVCNMSIEAGARAGMIAPDDTTYEFLRDRPHAPKGAQWDAAMRYWQQLRTDPGAVFDTEVYLDAASLSPFVTWGTNPGQGVPLAAAVPDPELMTDDAERQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDLRVVADVLRGRKVAPGVRMLVVPGSMRVRAQAEAEGLGEVFTAAGAEWRQAGCSMCLGMNPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLD |
Interaction
Subunit
Heterodimer of LeuC and LeuD.
Structure
Sequence
- Sequence statusComplete
- Length476
- Mass (Da)50,398
- Last updated2007-01-09 v1
- Checksum9B527A95D5ABF7F6
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000479 EMBL· GenBank· DDBJ | ABK65213.1 EMBL· GenBank· DDBJ | Genomic DNA |