A0PJW8 · DAPL1_HUMAN

  • Protein
    Death-associated protein-like 1
  • Gene
    DAPL1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

May play a role in the early stages of epithelial differentiation or in apoptosis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functiondeath domain binding
Molecular Functionribosome binding
Molecular Functiontranslation initiation factor binding
Molecular Functiontranslation repressor activity
Biological Processapoptotic signaling pathway
Biological Processcell differentiation
Biological Processcellular response to amino acid starvation
Biological Processnegative regulation of autophagy
Biological Processnegative regulation of CD8-positive, alpha-beta T cell activation
Biological Processribosome hibernation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Death-associated protein-like 1
  • Alternative names
    • Early epithelial differentiation-associated protein

Gene names

    • Name
      DAPL1
    • Synonyms
      EEDA

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0PJW8
  • Secondary accessions
    • A0PJW9
    • B9EIK6

Proteomes

Organism-specific databases

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_03840260in dbSNP:rs9869
Natural variantVAR_03840366in dbSNP:rs12535

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 140 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00003168351-107UniProtDeath-associated protein-like 1
Modified residue (large scale data)10PRIDEPhosphoserine

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in hair follicle (at protein level).

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-23Disordered

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    107
  • Mass (Da)
    11,880
  • Last updated
    2008-02-05 v2
  • Checksum
    2BB99D8DEB3FC7C3
MANEVQDLLSPRKGGHPPAVKAGGMRISKKQEIGTLERHTKKTGFEKTSAIANVAKIQTLDALNDALEKLNYKFPATVHMAHQKPTPALEKVVPLKRIYIIQQPRKC

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
H0Y3U5H0Y3U5_HUMANDAPL1174
B8ZZC6B8ZZC6_HUMANDAPL1113
M1EA23M1EA23_HUMANDAPL1134

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY324399
EMBL· GenBank· DDBJ
AAQ93012.1
EMBL· GenBank· DDBJ
mRNA
CH471058
EMBL· GenBank· DDBJ
EAX11424.1
EMBL· GenBank· DDBJ
Genomic DNA
BC127682
EMBL· GenBank· DDBJ
AAI27683.1
EMBL· GenBank· DDBJ
mRNA
BC127683
EMBL· GenBank· DDBJ
AAI27684.1
EMBL· GenBank· DDBJ
mRNA
BC140719
EMBL· GenBank· DDBJ
AAI40720.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp