A0N0Q0 · A0N0Q0_HUMAN

  • Protein
    Chemokine (C-C motif) receptor 7
  • Gene
    CCR7
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentexternal side of plasma membrane
Cellular Componentmitochondrion
Molecular FunctionC-C motif chemokine 19 receptor activity
Molecular Functionchemokine (C-C motif) ligand 19 binding
Molecular Functionchemokine (C-C motif) ligand 21 binding
Biological Processcalcium-mediated signaling
Biological Processcell chemotaxis
Biological Processhomeostasis of number of cells
Biological Processimmune response
Biological Processinflammatory response
Biological Processmature conventional dendritic cell differentiation
Biological Processnegative regulation of interleukin-12 production
Biological Processnegative thymic T cell selection
Biological Processpositive regulation of cytosolic calcium ion concentration
Biological Processpositive regulation of dendritic cell antigen processing and presentation
Biological Processpositive regulation of dendritic cell chemotaxis
Biological Processpositive regulation of glycoprotein biosynthetic process involved in immunological synapse formation
Biological Processpositive regulation of humoral immune response
Biological Processpositive regulation of hypersensitivity
Biological Processpositive regulation of immunological synapse formation
Biological Processpositive regulation of interleukin-12 production
Biological Processpositive regulation of neutrophil chemotaxis
Biological Processpositive regulation of T cell costimulation
Biological Processpositive regulation of T cell receptor signaling pathway
Biological Processregulation of interleukin-1 beta production
Biological Processregulation of type II interferon production
Biological Processresponse to lipopolysaccharide

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Chemokine (C-C motif) receptor 7
    • cDNA FLJ45911 fis, clone PEBLM2005615, highly similar to C-C chemokine receptor type 7

Gene names

    • Name
      CCR7
    • ORF names
      hCG_1643840

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0N0Q0

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane59-84Helical
Transmembrane96-116Helical
Transmembrane122-150Helical
Transmembrane171-191Helical
Transmembrane225-249Helical
Transmembrane261-279Helical
Transmembrane310-329Helical

Keywords

Disease & Variants

Organism-specific databases

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-24
ChainPRO_501429652025-378

Expression

Gene expression databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain75-326G-protein coupled receptors family 1 profile

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    378
  • Mass (Da)
    42,874
  • Last updated
    2006-12-12 v1
  • Checksum
    D4CB4213841A1BD4
MDLGKPMKSVLVVALLVIFQVCLCQDEVTDDYIGDNTTVDYTLFESLCSKKDVRNFKAWFLPIMYSIICFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNLAVADILFLLTLPFWAYSAAKSWVFGVHFCKLIFAIYKMSFFSGMLLLLCISIDRYVAIVQAVSAHRHRARVLLISKLSCVGIWILATVLSIPELLYSDLQRSSSEQAMRCSLITEHVEAFITIQVAQMVIGFLVPLLAMSFCYLVIIRTLLQARNFERNKAIKVIIAVVVVFIVFQLPYNGVVLAQTVANFNITSSTCELSKQLNIAYDVTYSLACVRCCVNPFLYAFIGVKFRNDLFKLFKDLGCLSQEQLRQWSSCRHIRRSSMSVEAETTTTFSP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EF064758
EMBL· GenBank· DDBJ
ABK41941.1
EMBL· GenBank· DDBJ
Genomic DNA
AK127810
EMBL· GenBank· DDBJ
BAG54575.1
EMBL· GenBank· DDBJ
mRNA
CH471152
EMBL· GenBank· DDBJ
EAW60669.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp