A0MGZ7 · H6S3B_DANRE

Function

function

6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.

Catalytic activity

Features

Showing features for binding site, active site.

141950100150200250300350400
TypeIDPosition(s)Description
Binding site101-1093'-phosphoadenylyl sulfate (UniProtKB | ChEBI)
Binding site131-132substrate
Binding site148substrate
Binding site153substrate
Active site158Proton acceptor
Binding site158substrate
Binding site1913'-phosphoadenylyl sulfate (UniProtKB | ChEBI)
Binding site1993'-phosphoadenylyl sulfate (UniProtKB | ChEBI)
Binding site203substrate
Binding site210substrate
Binding site323-3253'-phosphoadenylyl sulfate (UniProtKB | ChEBI)
Binding site329-3303'-phosphoadenylyl sulfate (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Molecular Function3'-phosphoadenosine 5'-phosphosulfate binding
Molecular Functionheparan sulfate 6-O-sulfotransferase activity
Molecular Functionoligosaccharide binding
Molecular Functionsulfotransferase activity
Biological Processheparan sulfate proteoglycan biosynthetic process, enzymatic modification

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Heparan-sulfate 6-O-sulfotransferase 3-B
  • EC number
  • Short names
    HS 6-OST-3-B

Gene names

    • Name
      hs6st3b

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    A0MGZ7

Proteomes

    • Identifier
    • Component
      Alternate scaffold 9, Chromosome 9

Organism-specific databases

Subcellular Location

Membrane
; Single-pass type II membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-7Cytoplasmic
Transmembrane8-28Helical; Signal-anchor for type II membrane protein
Topological domain29-419Lumenal

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis101Significantly impairs catalytic activity.
Mutagenesis104Significantly impairs catalytic activity.
Mutagenesis131Slightly impairs catalytic activity.
Mutagenesis132Significantly impairs catalytic activity.
Mutagenesis148Moderately impairs catalytic activity.
Mutagenesis153Moderately impairs catalytic activity.
Mutagenesis158Abolishes catalytic activity.
Mutagenesis203Significantly impairs catalytic activity.
Mutagenesis210Significantly impairs catalytic activity.

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00002838201-419Heparan-sulfate 6-O-sulfotransferase 3-B
Glycosylation77N-linked (GlcNAc...) asparagine
Glycosylation270N-linked (GlcNAc...) asparagine
Glycosylation275N-linked (GlcNAc...) asparagine
Glycosylation326N-linked (GlcNAc...) asparagine
Glycosylation393N-linked (GlcNAc...) asparagine
Glycosylation402N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

In early somitogenesis, expressed in presumptive forebrain and midbrain, tail bud and Kupffer's vesicle. During mid-somitogenesis, ubiquitous expression which is strongest in the somites and eye. During late somitogenesis, predominantly expressed in eye, hindbrain and ventral somites. At 24 hours post-fertilization (hpf), restricted to lens and neural retina, brain, otic vesicle and somites. At 36 hpf, brain expression is restricted to telencephalon. At 48 hpf, restricted to telencephalon and pectoral fin.

Developmental stage

Expressed both maternally and zygotically.

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the sulfotransferase 6 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    419
  • Mass (Da)
    49,346
  • Last updated
    2006-12-12 v1
  • Checksum
    D83CDCF7356749B5
MNDKPNKWIFIPILAILFVMIGYQYVCPAGGQACHFRTGDKLVRIAPLATPDPTTDDLYREQDPEEDNPPKCASKFNFTERDLTRDVDFNIKGDDVIVFLHIQKTGGTTFGRHLVRNIRLEQPCDCKAGQKKCTCHRPGKQESWLFSRFSTGWSCGLHADWTELTNCVPVIMDKRQPPKRKRNFYYITMLRDPVSRYLSEWKHVQRGATWKTSLHMCDGRSPTQDELPTCYNGDDWSGVTLHDFMDCPSNLANNRQVRMLADLSLVGCYNLSTMNESERNPILLASAKSNLKNMAFYGLTEFQRKTQYLFERTFHLRFISAFTQINSTRAANVELRDDMRSRIEQLNMLDMQLYEFAKDLFLQRYQFVRQRERQEERLKRREERRWIRERRVNQSKEPIVENQTRVTTTEDYASQVVRW

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ812996
EMBL· GenBank· DDBJ
ABH11458.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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